| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
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| Ligand | BDBM155971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro Competitive Displacement Binding Assays |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 5900±n/a nM |
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| Comments | extracted |
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| Citation |  Woolford, AJ; Howard, S; Buck, IM; Chessari, G; Johnson, CN; Tamanini, E; Day, JE; Chiarparin, E; Heightman, TD; Frederickson, M; Griffiths-Jones, CM Bicyclic heterocycle compounds and their uses in therapy US Patent US9018214 Publication Date 4/28/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase XIAP |
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| Name: | E3 ubiquitin-protein ligase XIAP |
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| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56685.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170 |
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| Residue: | 497 |
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| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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| BDBM155971 |
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| n/a |
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| Name | BDBM155971 |
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| Synonyms: | US9018214, 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20F3N3O |
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| Mol. Mass. | 327.3447 |
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| SMILES | C[C@@H]1CN(CC(=O)N2CCc3ccc(cc23)C(F)(F)F)CCN1 |r| |
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| Structure | 
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