Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM159766 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 13±n/a nM | ||
Comments | extracted | ||
Citation | Brown, MF; Fenwick, AE; Flanagan, ME; Gonzales, A; Johnson, TA; Kaila, N; Mitton-Fry, MJ; Strohbach, JW; TenBrink, RE; Trzupek, JD; Unwalla, RJ; Vazquez, ML; Parikh, MD Pyrrolo[2,3-D]pyrimidine derivatives US Patent US9035074 Publication Date 5/19/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM159766 | |||
n/a | |||
Name | BDBM159766 | ||
Synonyms: | US10966980, Example 17B | US9035074, 17B | ||
Type | Small organic molecule | ||
Emp. Form. | C16H21N7O2S | ||
Mol. Mass. | 375.449 | ||
SMILES | CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N1CC[C@@H](C1)C#N)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,13.16,(-5.79,1.48,;-4.45,.71,;-3.12,1.48,;-2.72,2.97,;-1.23,2.57,;-1.63,1.09,;.1,3.34,;1.43,2.57,;.66,1.24,;2.2,3.91,;2.77,1.8,;4.25,2.27,;5.15,1.03,;4.25,-.22,;2.78,.26,;5.02,-1.55,;5.79,-2.89,;-4.45,-.83,;-5.79,-1.6,;-5.79,-3.14,;-4.45,-3.91,;-3.12,-3.14,;-1.66,-3.61,;-.75,-2.37,;-1.66,-1.12,;-3.12,-1.6,)| | ||
Structure |