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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-secretase 1 | ||
| Ligand | BDBM160693 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Quenching Assay (FRET) | ||
| pH | 4.4±n/a | ||
| IC50 | 6±n/a nM | ||
| Comments | extracted | ||
| Citation |  Dillard, LW; Yuan, J; Leftheris, K; Venkatraman, S; Wu, G; Jia, L; Xu, Z; Cacatian, S; Morales-Ramos, A; Singh, SB; Zheng, Y Inhibitors of beta-secretase US Patent US9045500 Publication Date 6/2/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Beta-secretase 1 | |||
| Name: | Beta-secretase 1 | ||
| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 55755.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P56817 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| BDBM160693 | |||
| n/a | |||
| Name | BDBM160693 | ||
| Synonyms: | US9045500, 15 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H27N3O | ||
| Mol. Mass. | 433.5442 | ||
| SMILES | COC1CCC2(Cc3ccc(cc3C22N=C(N)c3ccccc23)-c2cccc(c2)C#N)CC1 |t:16,(7.84,-2.37,;6.5,-3.14,;5.17,-2.37,;4.08,-3.46,;2.74,-2.69,;1.2,-2.69,;.3,-3.94,;-1.17,-3.47,;-2.5,-4.23,;-3.84,-3.47,;-3.84,-1.93,;-2.5,-1.15,;-1.17,-1.93,;.3,-1.45,;-.9,-.48,;-.35,.96,;-1.12,2.29,;1.19,.88,;2.28,1.97,;3.77,1.57,;4.16,.08,;3.08,-1.01,;1.59,-.61,;-5.17,-1.15,;-6.5,-1.93,;-7.84,-1.15,;-7.84,.38,;-6.5,1.15,;-5.17,.38,;-6.5,2.69,;-6.5,4.23,;2.29,-1.61,;3.63,-2.37,)| | ||
| Structure | 
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