| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein Mdm4 |
|---|
| Ligand | BDBM161864 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay |
|---|
| IC50 | 19320±n/a nM |
|---|
| Citation |  Berghausen, J; Buschmann, N; Furet, P; Gessier, F; Hergovich Lisztwan, J; Holzer, P; Jacoby, E; Kallen, J; Masuya, K; Pissot Soldermann, C; Ren, H; Stutz, S Substituted isoquinolinones and quinazolinones US Patent US9051279 Publication Date 6/9/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein Mdm4 |
|---|
| Name: | Protein Mdm4 |
|---|
| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
|---|
| Type: | Oncoprotein |
|---|
| Mol. Mass.: | 54842.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
|---|
| Residue: | 490 |
|---|
| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
|
|
|
|---|
| BDBM161864 |
|---|
| n/a |
|---|
| Name | BDBM161864 |
|---|
| Synonyms: | US9051279, 42 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H34ClN3O3 |
|---|
| Mol. Mass. | 556.094 |
|---|
| SMILES | CC[C@@H](C)Oc1cc2C(N(C(=O)Cc2cc1OC)c1ccc(cc1)N(C)Cc1ccncc1)c1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
