| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM163619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC Activity Assays |
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| IC50 | 2.83e+3±n/a nM |
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| Citation |  Wang, Y; Stowe, RL; Pinello, CE; Tian, G; Madoux, F; Li, D; Zhao, LY; Li, JL; Wang, Y; Wang, Y; Ma, H; Hodder, P; Roush, WR; Liao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol22:273-84 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM163619 |
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| n/a |
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| Name | BDBM163619 |
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| Synonyms: | UF010 | US10807944, Compound UF010 | US11731934, Compound UF010 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15BrN2O |
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| Mol. Mass. | 271.154 |
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| SMILES | CCCCNNC(=O)c1ccc(Br)cc1 |
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| Structure | 
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