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TargetBeta-glucuronidase (SaGUS)
LigandBDBM163640
Substrate/Competitorn/a
Meas. Tech.Inhibition Assays
Ki 8.1e+2± 2e+2 nM
Citation Wallace BDRoberts ABPollet RMIngle JDBiernat KAPellock SJVenkatesh MKGuthrie LO'Neal SKRobinson SJDollinger MFigueroa EMcShane SRCohen RDJin JFrye SVZamboni WCPepe-Ranney CMani SKelly LRedinbo MR Structure and Inhibition of Microbiome -Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chem Biol 22:1238-49 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-glucuronidase (SaGUS)
Name:Beta-glucuronidase (SaGUS)
Synonyms:n/a
Type:Protein
Mol. Mass.:69235.31
Organism:Streptococcus agalactiae (Firmicutes)
Description:A0A0E1EGE5
Residue:599
Sequence:
MLYPLLTKTRNTYDLGGIWNFKLGEHNPNELLPSDEVMVIPTSFNDLMVSKEKRDYIGDF
WYEKVIEVPKVSEGEEMVLRFGSVTHQAKIYVDGILVGEHKGGFTPFEVLVPECKYNNEK
IKVSICANNVLDYTTLPVGNYSEIIQEDGSIKKKVRENFDFFNYAGVHRPLKLMIRPKNH
ISDITITSRLSDDLQSADLHFLVETNQKVDEVRISVFDEDNKLVGETKDSRLFLSDVHLW
EVLNAYLYTARVEIFVDNQLQDVYEENFGLREIEVTNGQFLLNRKPIYFKGFGKHEDTFI
NGRGLNEAANLMDLNLLKDIGANSFRTSHYPYSEEMMRLADRMGVLVIDEVPAVGLFQNF
NASLDLSPKDNGTWSLMQTKAAHEQAIQELVKRDKNHPSVVMWVVANEPASHEAGAHDYF
EPLVKLYKDLDPQKRPVTLVNILMATPDRDQVMDLVDVVCLNRYYGWYVDHGDLTNAEVG
LRKELLEWQDKFPDKPIIITEYGADTLPGLHSTWNIPYTEEFQCDFYEMSHRVFDGIPNL
VGEQVWNFADFETNLMILRVQGNHKGLFSRNRQPKQVVKEFKKRWMTIPHYHNKKNSVK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM163640
n/a
NameBDBM163640
Synonyms:5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7.4.0.0,⁷]trideca1(9),2(7),3,5tetraene (Inh 5) | US9334288, 5
TypeSmall organic molecule
Emp. Form.C16H22N4S
Mol. Mass.302.438
SMILESCC1CCc2c(C1)sc1nc(C)nc(N3CCNCC3)c21
Structure
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