| Reaction Details |
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 | Report a problem with these data |
| Target | Pancreatic alpha-amylase |
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| Ligand | BDBM163646 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinetic Studies |
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| Temperature | 303.15±0 K |
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| Ki | 8.1±0.8 nM |
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| Citation |  Williams, LK; Zhang, X; Caner, S; Tysoe, C; Nguyen, NT; Wicki, J; Williams, DE; Coleman, J; McNeill, JH; Yuen, V; Andersen, RJ; Withers, SG; Brayer, GD The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif. Nat Chem Biol11:691-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pancreatic alpha-amylase |
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| Name: | Pancreatic alpha-amylase |
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| Synonyms: | 1,4-alpha-D-glucan glucanohydrolase | AMY2A | AMYP_HUMAN | PA | Pancreatic α-amylase (HPA) | Pancreatic alpha-amylase | Pancreatic alpha-amylase (HPA) |
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| Type: | Protein |
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| Mol. Mass.: | 57709.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 511 |
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| Sequence: | MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP
NENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGN
AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGL
LDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAG
SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG
FVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP
RQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQP
FTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGI
KIYVSDDGKAHFSISNSAEDPFIAIHAESKL
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| BDBM163646 |
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| n/a |
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| Name | BDBM163646 |
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| Synonyms: | Montbretin A (MbA) |
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| Type | Small organic molecule |
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| Emp. Form. | C36H36O20 |
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| Mol. Mass. | 788.659 |
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| SMILES | CC1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2cc(O)c(O)c(O)c2)[C@@H](O[C@@H]2OC(COC(=O)\C=C\c3ccc(O)c(O)c3)[C@@H](O)C(O)[C@@H]2O)C(O)[C@H]1O |r| |
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| Structure | 
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