| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carboxylic ester hydrolase |
|---|
| Ligand | BDBM173564 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AChE and BChE Inhibitory Activities |
|---|
| IC50 | 1.62e+4± 1.07e+3 nM |
|---|
| Citation |  Saeed, A; Zaib, S; Ashraf, S; Iftikhar, J; Muddassar, M; Zhang, KY; Iqbal, J Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. Bioorg Chem63:58-63 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carboxylic ester hydrolase |
|---|
| Name: | Carboxylic ester hydrolase |
|---|
| Synonyms: | BuChE | Butyrlcholinesterase (BuChE) | Butyrylcholine esterase | Butyrylcholinesterase | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | Butyrylcholinesterase (EqBuChE) | Carboxylic ester hydrolase | butyrylcholinesterase precursor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68842.83 |
|---|
| Organism: | Equus caballus (Horse) |
|---|
| Description: | Q9N1N9 |
|---|
| Residue: | 602 |
|---|
| Sequence: | MQSWGTIICIRILLRFLLLWVLIGNSHTEEDIIITTKNGKVRGMNLPVLGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDC
LYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALG
FLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPR
SQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEI
LLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDV
VGDYNIICPALEFTKKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLER
RVNYTKAEEILSRSIMKRWANFAKYGNPNGTQSNSTRWPVFKSTEQKYLTLNTESPKVYT
KLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCS
DF
|
|
|
|---|
| BDBM173564 |
|---|
| n/a |
|---|
| Name | BDBM173564 |
|---|
| Synonyms: | 1-(2-Oxo-2H-chromene-3-carbonyl)-3-(3-fluorophenyl)thiourea (2c) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H11FN2O3S |
|---|
| Mol. Mass. | 342.344 |
|---|
| SMILES | Fc1cccc(NC(=S)NC(=O)c2cc3ccccc3oc2=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
