| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Ligand | BDBM60635 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity Assay (SPA) |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 5.37±n/a nM |
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| Comments | extracted |
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| Citation |  Schmidt, B; Scheufler, C; Volz, J; Feth, M; Hummel, R; Hatzelmann, A; Zitt, C; Wohlsen, A; Marx, D; Kley, H; Ockert, D; Heuser, A; Christiaans, JA; Sterk, GJ; Menge, WM Pyrazolone derivatives as PDE4 inhibitors US Patent US8865745 Publication Date 10/21/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
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| Type: | Protein |
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| Mol. Mass.: | 83318.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07343 |
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| Residue: | 736 |
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| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
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| BDBM60635 |
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| n/a |
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| Name | BDBM60635 |
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| Synonyms: | US8865745, 17 |
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| Type | n/a |
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| Emp. Form. | C24H30N4O6S |
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| Mol. Mass. | 502.583 |
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| SMILES | COc1ccc(cc1OC)C1=NN(C2CCN(CC2)C(=O)CN2C(=O)CSCC2=O)C(=O)C1(C)C |t:11| |
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| Structure | 
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