Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM185316 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescent Imaging Plate Reader (FLIPR) Assay |
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Temperature | 310.15±n/a K |
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IC50 | 34±n/a nM |
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Comments | extracted |
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Citation | Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS Cycloalkyl and heterocycloalkyl compounds as orexin receptor antagonists US Patent US9156829 Publication Date 10/13/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM185316 |
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n/a |
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Name | BDBM185316 |
Synonyms: | US10011588, Example 137 | US10689373, Example 137 | US9156829, 137 |
Type | Small organic molecule |
Emp. Form. | C22H21F3N6O |
Mol. Mass. | 442.4369 |
SMILES | Cc1cc(cnc1N[C@H]1CCC[C@@H]1NC(=O)c1ncccc1-c1ncccn1)C(F)(F)F |r| |
Structure |
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