Reaction Details |
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Target | Tyrosyl-DNA phosphodiesterase 2 |
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Ligand | BDBM50438865 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Recombinant TDP2 Assay |
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pH | 7.5±n/a |
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IC50 | 3.0e+2± 6e+1 nM |
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Comments | extracted |
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Citation | Marchand, C; Abdelmalak, M; Kankanala, J; Huang, SY; Kiselev, E; Fesen, K; Kurahashi, K; Sasanuma, H; Takeda, S; Aihara, H; Wang, Z; Pommier, Y Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. ACS Chem Biol11:1925-33 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosyl-DNA phosphodiesterase 2 |
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Name: | Tyrosyl-DNA phosphodiesterase 2 |
Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40916.54 |
Organism: | Homo sapiens (Human) |
Description: | gi_23510348 |
Residue: | 362 |
Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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BDBM50438865 |
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n/a |
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Name | BDBM50438865 |
Synonyms: | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-carbonitrile (3) | CHEMBL2420506 |
Type | Small organic molecule |
Emp. Form. | C18H10N4O2 |
Mol. Mass. | 314.2976 |
SMILES | O=c1nc2n(-c3ccccc3)c3cc(ccc3cc2c(=O)[nH]1)C#N |
Structure |
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