| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 2 |
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| Ligand | BDBM188529 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TDP2 Assays with Whole Cell Extracts |
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| pH | 7.5±n/a |
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| IC50 | 25±n/a nM |
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| Comments | extracted |
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| Citation |  Marchand, C; Abdelmalak, M; Kankanala, J; Huang, SY; Kiselev, E; Fesen, K; Kurahashi, K; Sasanuma, H; Takeda, S; Aihara, H; Wang, Z; Pommier, Y Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. ACS Chem Biol11:1925-33 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 2 |
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| Name: | Tyrosyl-DNA phosphodiesterase 2 |
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| Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40916.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_23510348 |
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| Residue: | 362 |
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| Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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| BDBM188529 |
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| n/a |
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| Name | BDBM188529 |
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| Synonyms: | 2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[4,5-b]-quinoline-8-carbonitrile (1) |
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| Type | Small organic molecule |
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| Emp. Form. | C19H10N8O2 |
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| Mol. Mass. | 382.3351 |
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| SMILES | O=c1nc2n(-c3cccc(c3)-n3cnnn3)c3cc(ccc3cc2c(=O)[nH]1)C#N |
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| Structure | 
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