| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM38052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Bak Peptide Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 30000±n/a nM |
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| Comments | extracted |
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| Citation |  Chen, CH; Chen, Z; Fortanet, JG; Grunenfelder, D; Karki, R; Kato, M; LaMarche, MJ; Perez, LB; Stams, TM; Williams, S 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 US Patent US10093646 Publication Date 10/9/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM38052 |
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| n/a |
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| Name | BDBM38052 |
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| Synonyms: | N-(methylsulfonyl)-3-(3-(p-tolyloxy)propyl)-1H-indole-2-carboxamide | US10093640, Example 33 | US10844032, Example 33 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O4S |
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| Mol. Mass. | 386.465 |
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| SMILES | Cc1ccc(OCCCc2c([nH]c3ccccc23)C(=O)NS(C)(=O)=O)cc1 |
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| Structure | 
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