| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 [1-458] |
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| Ligand | BDBM195379 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BACE Enzyme Assay (Ex.434) |
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| pH | 4.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.1±n/a nM |
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| Comments | extracted |
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| Citation |  Cacatian, S; Claremon, DA; Dillard, LW; Fuchs, K; Heine, N; Jia, L; Leftheris, K; McKeever, B; Morales-Ramos, A; Singh, SB; Venkatraman, S; Wu, G; Wu, Z; Xu, Z; Yuan, J; Zheng, Y Inhibitors of beta-secretase US Patent US9212153 Publication Date 12/15/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-secretase 1 [1-458] |
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| Name: | Beta-secretase 1 [1-458] |
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| Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (aa 1-458) | KIAA1149 |
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| Type: | n/a |
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| Mol. Mass.: | 50753.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Truncation 1-458 aa with His-tag at C-terminus |
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| Residue: | 458 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTI
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| BDBM195379 |
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| n/a |
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| Name | BDBM195379 |
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| Synonyms: | US10336717, Compound 463 | US9212153, 463,Ex. 397 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22ClFN4O2 |
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| Mol. Mass. | 464.919 |
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| SMILES | CN1C(N)=NC2(C1=O)c1cc(ccc1CC21CCc2noc(C)c2C1)-c1cc(F)cc(Cl)c1 |c:3| |
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| Structure | 
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