Reaction Details |
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Target | L-lactate dehydrogenase B chain |
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Ligand | BDBM197158 |
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Substrate/Competitor | n/a |
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Meas. Tech. | LHDA/LDHB Enzymatic Assays |
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IC50 | 1.8e+4±n/a nM |
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Citation | Boudreau, A; Purkey, HE; Hitz, A; Robarge, K; Peterson, D; Labadie, S; Kwong, M; Hong, R; Gao, M; Del Nagro, C; Pusapati, R; Ma, S; Salphati, L; Pang, J; Zhou, A; Lai, T; Li, Y; Chen, Z; Wei, B; Yen, I; Sideris, S; McCleland, M; Firestein, R; Corson, L; Vanderbilt, A; Williams, S; Daemen, A; Belvin, M; Eigenbrot, C; Jackson, PK; Malek, S; Hatzivassiliou, G; Sampath, D; Evangelista, M; O'Brien, T Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat Chem Biol12:779-86 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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L-lactate dehydrogenase B chain |
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Name: | L-lactate dehydrogenase B chain |
Synonyms: | L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46 |
Type: | Oxidoreductase; homotetramer |
Mol. Mass.: | 36635.55 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 334 |
Sequence: | MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
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BDBM197158 |
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n/a |
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Name | BDBM197158 |
Synonyms: | 3-((2-chlorophenyl)thio)-4-hydroxy-6-phenyl-5,6-dihydropyridin-2(1H)-one (4) |
Type | Small organic molecule |
Emp. Form. | C17H14ClNO2S |
Mol. Mass. | 331.817 |
SMILES | OC1=C(Sc2ccccc2Cl)C(=O)NC(C1)c1ccccc1 |w:14.17,c:1| |
Structure |
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