| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
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| Ligand | BDBM197160 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LHDA/LDHB Enzymatic Assays |
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| IC50 | 3±n/a nM |
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| Citation |  Boudreau, A; Purkey, HE; Hitz, A; Robarge, K; Peterson, D; Labadie, S; Kwong, M; Hong, R; Gao, M; Del Nagro, C; Pusapati, R; Ma, S; Salphati, L; Pang, J; Zhou, A; Lai, T; Li, Y; Chen, Z; Wei, B; Yen, I; Sideris, S; McCleland, M; Firestein, R; Corson, L; Vanderbilt, A; Williams, S; Daemen, A; Belvin, M; Eigenbrot, C; Jackson, PK; Malek, S; Hatzivassiliou, G; Sampath, D; Evangelista, M; O'Brien, T Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat Chem Biol12:779-86 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| L-lactate dehydrogenase A chain |
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| Name: | L-lactate dehydrogenase A chain |
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| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
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| Type: | Protein |
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| Mol. Mass.: | 36694.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00338::PDB Code: 4ajp |
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| Residue: | 332 |
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| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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| BDBM197160 |
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| n/a |
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| Name | BDBM197160 |
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| Synonyms: | GNE-140 (6) |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23ClN2O3S2 |
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| Mol. Mass. | 499.045 |
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| SMILES | OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1 |r,c:1| |
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| Structure | 
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