| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 2 [596-900] |
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| Ligand | BDBM209864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinobeads Competition Assay |
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| Kd | 484±0.0 nM |
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| Citation |  Heinzlmeir, S; Kudlinzki, D; Sreeramulu, S; Klaeger, S; Gande, SL; Linhard, V; Wilhelm, M; Qiao, H; Helm, D; Ruprecht, B; Saxena, K; Médard, G; Schwalbe, H; Kuster, B Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol11:3400-3411 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 2 [596-900] |
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| Name: | Ephrin type-A receptor 2 [596-900] |
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| Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin type-A receptor 2 (EPHA2) |
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| Type: | Protein |
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| Mol. Mass.: | 34367.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EPHA2 truncation (596-900 aa); 519U |
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| Residue: | 305 |
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| Sequence: | DPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK
QRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQ
LVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS
GGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR
LPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRL
PSTSG
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| BDBM209864 |
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| n/a |
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| Name | BDBM209864 |
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| Synonyms: | 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide | MLN-2480 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Cl2F3N7O2S |
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| Mol. Mass. | 506.289 |
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| SMILES | C[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(s1)C(=O)Nc1cc(c(Cl)cn1)C(F)(F)F |
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| Structure | 
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