Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Ephrin type-A receptor 2 [596-900] | ||
Ligand | BDBM6568 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinobeads Competition Assay | ||
Kd | 46±0.0 nM | ||
Citation | Heinzlmeir, S; Kudlinzki, D; Sreeramulu, S; Klaeger, S; Gande, SL; Linhard, V; Wilhelm, M; Qiao, H; Helm, D; Ruprecht, B; Saxena, K; Médard, G; Schwalbe, H; Kuster, B Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol11:3400-3411 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Ephrin type-A receptor 2 [596-900] | |||
Name: | Ephrin type-A receptor 2 [596-900] | ||
Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin type-A receptor 2 (EPHA2) | ||
Type: | Protein | ||
Mol. Mass.: | 34367.96 | ||
Organism: | Homo sapiens (Human) | ||
Description: | EPHA2 truncation (596-900 aa); 519U | ||
Residue: | 305 | ||
Sequence: |
| ||
BDBM6568 | |||
n/a | |||
Name | BDBM6568 | ||
Synonyms: | 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL386051 | PD-173955 | PD173955 | US11136333, Compound PD173955 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H16Cl2N4OS | ||
Mol. Mass. | 443.349 | ||
SMILES | CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-12.18,1.86,;-10.84,1.09,;-9.51,1.86,;-9.51,3.4,;-8.18,4.17,;-6.84,3.4,;-6.84,1.86,;-5.51,1.08,;-4.18,1.85,;-4.18,3.39,;-2.84,4.16,;-1.51,3.4,;-.18,4.17,;1.16,3.4,;2.49,4.17,;2.49,5.71,;1.16,6.48,;3.83,6.48,;5.16,5.71,;5.16,4.17,;3.83,3.39,;3.83,1.85,;1.16,1.86,;2.49,1.09,;-.18,1.09,;-.18,-.45,;-1.51,1.86,;-2.84,1.08,;-8.18,1.08,)| | ||
Structure |