| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase plasminogen activator surface receptor |
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| Ligand | BDBM222357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Assay |
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| Ki | 1900±400 nM |
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| IC50 | 30100±2600 nM |
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| Citation |  Liu, D; Xu, D; Liu, M; Knabe, WE; Yuan, C; Zhou, D; Huang, M; Meroueh, SO Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction. Biochemistry56:1768-1784 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urokinase plasminogen activator surface receptor |
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| Name: | Urokinase plasminogen activator surface receptor |
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| Synonyms: | CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | UPAR_HUMAN | Urokinase plasminogen activator surface receptor | Urokinase receptor (uPAR) | Urokinase-type plasminogen activator/surface receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 36979.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q03405 |
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| Residue: | 335 |
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| Sequence: | MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
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| BDBM222357 |
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| n/a |
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| Name | BDBM222357 |
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| Synonyms: | IPR-1192 (10) |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16BrClFNO3 |
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| Mol. Mass. | 500.744 |
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| SMILES | Cc1ccc(cc1Br)N1C(C(C(=O)c2ccc(Cl)cc2)=C(O)C1=O)c1ccccc1F |t:21| |
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| Structure | 
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