Reaction Details |
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Target | Urokinase plasminogen activator surface receptor |
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Ligand | BDBM222385 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Polarization Assay |
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Ki | 2300±200 nM |
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Citation | Liu, D; Xu, D; Liu, M; Knabe, WE; Yuan, C; Zhou, D; Huang, M; Meroueh, SO Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction. Biochemistry56:1768-1784 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Urokinase plasminogen activator surface receptor |
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Name: | Urokinase plasminogen activator surface receptor |
Synonyms: | CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | UPAR_HUMAN | Urokinase plasminogen activator surface receptor | Urokinase receptor (uPAR) | Urokinase-type plasminogen activator/surface receptor |
Type: | Receptor |
Mol. Mass.: | 36979.14 |
Organism: | Homo sapiens (Human) |
Description: | Q03405 |
Residue: | 335 |
Sequence: | MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
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BDBM222385 |
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n/a |
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Name | BDBM222385 |
Synonyms: | IPR-1167 (38) |
Type | Small organic molecule |
Emp. Form. | C25H17Cl3FNO3 |
Mol. Mass. | 504.765 |
SMILES | OC1=C(C(N(CCc2ccc(Cl)cc2Cl)C1=O)c1cccc(F)c1)C(=O)c1ccc(Cl)cc1 |t:1| |
Structure |
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