| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-nucleotidase |
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| Ligand | BDBM223077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Ecto-5'-Nucleotidase Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 680±10.0 nM |
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| Comments | extracted |
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| Citation |  Channar, PA; Shah, SJ; Hassan, S; Nisa, ZU; Lecka, J; Sévigny, J; Bajorath, J; Saeed, A; Iqbal, J Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase. Chem Biol Drug Des89:365-370 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-nucleotidase |
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| Name: | 5'-nucleotidase |
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| Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
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| Type: | Enzyme |
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| Mol. Mass.: | 63371.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21589 |
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| Residue: | 574 |
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| Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
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| BDBM223077 |
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| n/a |
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| Name | BDBM223077 |
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| Synonyms: | (E)-N'-(4'-Hydroxy-3-methoxybenzylidene)isonicotinohydrazide (3g) |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N3O3 |
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| Mol. Mass. | 271.2713 |
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| SMILES | COc1cc(\C=N\NC(=O)c2ccncc2)ccc1O |
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| Structure | 
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