Reaction Details |
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Target | 5'-nucleotidase |
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Ligand | BDBM223080 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ecto-5'-Nucleotidase Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 190±20 nM |
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Comments | extracted |
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Citation | Channar, PA; Shah, SJ; Hassan, S; Nisa, ZU; Lecka, J; Sévigny, J; Bajorath, J; Saeed, A; Iqbal, J Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase. Chem Biol Drug Des89:365-370 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5'-nucleotidase |
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Name: | 5'-nucleotidase |
Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
Type: | Enzyme |
Mol. Mass.: | 63371.54 |
Organism: | Homo sapiens (Human) |
Description: | P21589 |
Residue: | 574 |
Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
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BDBM223080 |
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n/a |
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Name | BDBM223080 |
Synonyms: | (E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1yl)ethylidene)isonicotino hydrazide (3j) |
Type | Small organic molecule |
Emp. Form. | C23H20FN5O |
Mol. Mass. | 401.4362 |
SMILES | C\C(=N/NC(=O)c1ccncc1)N1N=C(CC1c1ccccc1)c1ccc(F)cc1 |c:14| |
Structure |
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