| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal oxygenase 1 |
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| Ligand | BDBM223320 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RapidFire MS Assay |
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| IC50 | <1e+5±NaN nM |
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| Citation |  Tumber, A; Nuzzi, A; Hookway, ES; Hatch, SB; Velupillai, S; Johansson, C; Kawamura, A; Savitsky, P; Yapp, C; Szykowska, A; Wu, N; Bountra, C; Strain-Damerell, C; Burgess-Brown, NA; Ruda, GF; Fedorov, O; Munro, S; England, KS; Nowak, RP; Schofield, CJ; La Thangue, NB; Pawlyn, C; Davies, F; Morgan, G; Athanasou, N; Müller, S; Oppermann, U; Brennan, PE Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol24:371-380 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal oxygenase 1 |
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| Name: | Ribosomal oxygenase 1 |
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| Synonyms: | C14orf169 | Histone lysine demethylase NO66 (NO66) | MAPJD | NO66 | RIOX1 | RIOX1_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 71083.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H6W3 |
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| Residue: | 641 |
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| Sequence: | MDGLQASAGPLRRGRPKRRRKPQPHSGSVLALPLRSRKIRKQLRSVVSRMAALRTQTLPS
ENSEESRVESTADDLGDALPGGAAVAAVPDAARREPYGHLGPAELLEASPAARSLQTPSA
RLVPASAPPARLVEVPAAPVRVVETSALLCTAQHLAAVQSSGAPATASGPQVDNTGGEPA
WDSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVRRQDHTYYQG
LFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRALPAAAWSLYQAGCSLRLLC
PQAFSTTVWQFLAVLQEQFGSMAGSNVYLTPPNSQGFAPHYDDIEAFVLQLEGRKLWRVY
RPRVPTEELALTSSPNFSQDDLGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTL
STYQRNTWGDFLEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEK
VRVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWEAGEPVNVGA
QLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEEPKCLEIYPQQADAMELLLG
SYPEFVRVGDLPCDSVEDQLSLATTLYDKGLLLTKMPLALN
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| BDBM223320 |
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| n/a |
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| Name | BDBM223320 |
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| Synonyms: | KDOAM-25 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H25N5O2 |
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| Mol. Mass. | 307.3913 |
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| SMILES | CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(N)=O |
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| Structure | 
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