| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase haspin [470-798] |
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| Ligand | BDBM224008 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Equilibrium Binding/Displacement Assay with Fluorescence Anisotropy |
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| pH | 7.5±n/a |
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| Kd | 0.14±0.05 nM |
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| Comments | extracted |
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| Citation |  Kestav, K; Viht, K; Konovalov, A; Enkvist, E; Uri, A; Lavogina, D Slowly on, Slowly off: Bisubstrate-Analogue Conjugates of 5-Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin. Chembiochem18:790-798 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase haspin [470-798] |
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| Name: | Serine/threonine-protein kinase haspin [470-798] |
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| Synonyms: | GSG2 | HASPIN | HASP_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 37470.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human haspin (470-798 aa) |
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| Residue: | 329 |
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| Sequence: | KGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTF
EEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSAND
RPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRD
LHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDED
LFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQ
IKRKIQEFHRTMLNFSSATDLLCQHSLFK
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| BDBM224008 |
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| n/a |
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| Name | BDBM224008 |
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| Synonyms: | ARC-3429 |
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| Type | Small organic molecule |
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| Emp. Form. | C60H104IN24O18 |
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| Mol. Mass. | 1576.5206 |
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| SMILES | CC(O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](CCCCNC(=O)C[C@@H](NC(=O)CCCCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(I)c2c(N)ncnc12)C([O-])=O)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](C)[NH3+])C(=O)N[C@@H](C)C(=O)N[C@H](CCCC[NH3+])C(N)=O |r| |
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| Structure | 
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