| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 1 |
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| Ligand | BDBM236795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Affinity Assay |
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| IC50 | 77.0±n/a nM |
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| Citation |  Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases US Patent US9580412 Publication Date 2/28/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 1 |
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| Name: | C-X-C chemokine receptor type 1 |
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| Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39803.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25024 |
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| Residue: | 350 |
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| Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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| BDBM236795 |
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| n/a |
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| Name | BDBM236795 |
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| Synonyms: | US9388149, 2 (Diastereoisomer 1) | US9388149, 2 (Diastereoisomer 2) | US9388149, 2 (Enantiomer 1 of diastereoisomer 1) | US9388149, 2 (Enantiomer 1 of diastereoisomer 2) | US9388149, 2 (Enantiomer 2 of diastereoisomer 1) | US9388149, 2 (Enantiomer 2 of diastereoisomer 2) | US9580412, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N3O5S |
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| Mol. Mass. | 455.527 |
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| SMILES | CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |
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| Structure | 
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