Ki Summary

Reaction Details

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Target

High affinity nerve growth factor receptor [441-796]

Ligand

BDBM226850

Substrate/Competitor

n/a

Meas. Tech.

Cell Based Assay

Temperature

310.15±n/a K

IC50

4.69±n/a nM

Comments

extracted

Citation

Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS Tropomyosin-related kinase inhibitors US Patent US9328096 Publication Date 5/3/2016

More Info.:

Get all data from this article, Assay Method

High affinity nerve growth factor receptor [441-796]

Name:

High affinity nerve growth factor receptor [441-796]

Synonyms:

Type:

Protein

Mol. Mass.:

39939.20

Organism:

Homo sapiens (Human)

Description:

Human his-tagged TrkA cytoplasmic domain (441-796 aa)

Residue:

356

Sequence:

KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

BDBM226850

n/a

Name

BDBM226850

Synonyms:

US9328096, 543

Type

Small organic molecule

Emp. Form.

C26H20Cl2FN5O3

Mol. Mass.

540.373

SMILES

O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 |wU:3.5,wD:1.0,(-5.13,-2.63,;-5.13,-1.09,;-4.04,-0,;-5.13,1.09,;-6.22,-0,;-5.13,2.63,;-3.8,3.4,;-3.8,4.94,;-2.46,2.63,;-2.3,1.09,;-.79,.77,;-.17,-.63,;-1.07,-1.88,;-2.6,-1.72,;-.45,-3.29,;-1.35,-4.53,;-.73,-5.94,;.81,-6.1,;1.43,-7.51,;1.71,-4.85,;1.08,-3.45,;1.99,-2.2,;-1.63,-7.18,;-3.16,-7.02,;-4.07,-8.27,;-3.44,-9.68,;-1.91,-9.84,;-1,-8.59,;.53,-8.75,;-.02,2.11,;-1.06,3.25,;1.51,2.27,;2.13,3.68,;3.66,3.84,;4.57,2.59,;3.94,1.18,;2.41,1.02,)|

Structure