Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHigh affinity nerve growth factor receptor [441-796]
LigandBDBM226929
Substrate/Competitorn/a
Meas. Tech.Cell Based Assay
Temperature310.15±n/a K
IC50 1.17±n/a nM
Commentsextracted
Citation Bagal, SKCui, JJGreasley, SELunney, EAMcAlpine, IJNagata, ANinkovic, SOmoto, KSkerratt, SEStorer, RIWarmus, JS Tropomyosin-related kinase inhibitors US Patent US9328096 Publication Date 5/3/2016
More Info.:Get all data from this article,  Assay Method
 
High affinity nerve growth factor receptor [441-796]
Name:High affinity nerve growth factor receptor [441-796]
Synonyms:MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A | Tyrosine kinase receptor A (TrkA)
Type:Protein
Mol. Mass.:39939.20
Organism:Homo sapiens (Human)
Description:Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM226929
n/a
NameBDBM226929
Synonyms:US9328096, 617
TypeSmall organic molecule
Emp. Form.C28H21Cl2N7O2
Mol. Mass.558.418
SMILESNc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)ccn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: