| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] |
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| Ligand | BDBM50012911 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Recruitment Assay |
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| pH | 7±n/a |
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| EC50 | 133±n/a nM |
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| Comments | extracted |
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| Citation |  Haynes, N; Kertesz, DJ; Pietranico-Cole, SL; Qian, Y; Scott, NR; So, S; Thakkar, KC; Tilley, JW Thyroid hormone analogs US Patent US Patent
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] |
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| Name: | Retinoic acid receptor RXR-alpha [225-462]/Thyroid hormone receptor beta [148-410] |
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| Synonyms: | Thyroid Hormone Receptor Beta/ Retinoid X Receptor |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Thyroid hormone receptor beta [148-410] |
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| Synonyms: | ERBA2 | NR1A2 | THB_HUMAN | THR1 | THRB | Thyroid hormone receptor beta |
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| Type: | Protein |
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| Mol. Mass.: | 29766.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | amino acids 148-410 |
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| Residue: | 263 |
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| Sequence: | EGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKS
IGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLE
AFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESET
LTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLA
CVERIEKYQDSFLLAFEHYINYR
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|
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| Component 2 |
| Name: | Retinoic acid receptor RXR-alpha [225-462] |
|---|
| Synonyms: | NR2B1 | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha |
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| Type: | Protein |
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| Mol. Mass.: | 26631.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | amino acids 225-462 |
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| Residue: | 238 |
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| Sequence: | SANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAK
RIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGA
IFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYC
KHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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| BDBM50012911 |
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| n/a |
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| Name | BDBM50012911 |
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| Synonyms: | CHEMBL3261332 | USRE46024, 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl2N6O3 |
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| Mol. Mass. | 433.248 |
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| SMILES | CC(C)c1cc(Cc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O |
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| Structure | 
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