Reaction Details |
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Target | Glycogen synthase kinase-3 beta [7-25] |
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Ligand | BDBM6416 |
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Substrate/Competitor | GSK-3 Peptide Substrate |
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Meas. Tech. | Kinase Inhibition Assay |
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IC50 | 478±n/a nM |
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Citation | Kuo, GH; Prouty, C; Wang, A; Emanuel, S; Deangelis, A; Zhang, Y; Song, F; Beall, L; Connolly, PJ; Karnachi, P; Chen, X; Gruninger, RH; Sechler, J; Fuentes-Pesquera, A; Middleton, SA; Jolliffe, L; Murray, WV Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors. J Med Chem48:4892-909 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Glycogen synthase kinase-3 beta [7-25] |
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Name: | Glycogen synthase kinase-3 beta [7-25] |
Synonyms: | G1T8E2_RABIT | GSK-3, beta | GSK3B | Glycogen Synthase Kinase-3, beta |
Type: | Enzyme fragment |
Mol. Mass.: | 1972.14 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | Glycogen Synthase Kinase-3 is the beta isoform of the rabbit enzyme produced in E.coli..
Only partial sequence is available. |
Residue: | 19 |
Sequence: | |
BDBM6416 |
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GSK-3 Peptide Substrate |
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Name: | GSK-3 Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 3277.76 |
Organism: | n/a |
Description: | n/a |
Residue: | 27 |
Sequence: | (Biotin)KRREILSRRP(phospho)SYR-Amide
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