| Reaction Details |
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 | Report a problem with these data |
| Target | Angiopoietin-1 receptor [776-1124] |
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| Ligand | BDBM239698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 0.7±n/a nM |
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| Comments | extracted |
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| Citation |  Süβmeier, F; Lobell, M; Grünewald, S; Härter, M; Buchmann, B; Telser, J; Jöriβen, H; Heroult, M; Kahnert, A; Lustig, K; Lindner, N Substituted phenylimidazopyrazoles and their use US Patent US9394309 Publication Date 7/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Angiopoietin-1 receptor [776-1124] |
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| Name: | Angiopoietin-1 receptor [776-1124] |
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| Synonyms: | TEK | TIE2 | TIE2_HUMAN | Tyrosine-protein kinase receptor TIE-2 | VMCM | VMCM1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39865.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | amino acids 776-1124 |
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| Residue: | 349 |
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| Sequence: | NVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNF
GQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHR
GYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYL
SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVY
TTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCW
REKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
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| BDBM239698 |
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| n/a |
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| Name | BDBM239698 |
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| Synonyms: | US9394309, 155 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28F5N5O3S |
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| Mol. Mass. | 621.621 |
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| SMILES | COCCOCc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1 |
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| Structure | 
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