Compile Data Set for Download or QSAR

Found 417 hits with Last Name = 'heroult' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239621 (US9394309, 147 | US9394309, 74) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM194899 (US9206184, 80) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)c(Cl)n2ncnc(N)c12 Show InChI InChI=1S/C21H21ClN6O2S/c1-11-5-12-7-15(31-19(12)14(6-11)30-2)17-13(8-27-4-3-24-16(29)9-27)20(22)28-18(17)21(23)25-10-26-28/h5-7,10H,3-4,8-9H2,1-2H3,(H,24,29)(H2,23,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.0	22
BAYER INTELLECTUAL PROPERTY GmbH US Patent					Assay Description For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...				US Patent US9206184 (2015) BindingDB Entry DOI: 10.7270/Q2SN07SH
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239596 (US9394309, 49) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C(C)(C)O)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C31H33N5O2/c1-20-9-10-25(33-29(37)22-14-23(30(2,3)4)16-24(15-22)31(5,6)38)17-27(20)35-12-13-36-28(35)18-26(34-36)21-8-7-11-32-19-21/h7-19,38H,1-6H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239708 (US9394309, 166) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cncnc1 Show InChI InChI=1S/C25H18F5N7OS/c1-15-5-16(2)23(36-3-4-37-24(36)10-22(35-37)19-12-32-14-33-13-19)9-21(15)34-25(38)18-6-17(11-31)7-20(8-18)39(26,27,28,29)30/h3-10,12-14H,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239696 (US9394309, 153) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(N)=O)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H23F5N6O2S/c1-16-8-17(2)24(37-6-7-38-26(37)14-23(36-38)19-4-3-5-34-15-19)13-22(16)35-27(40)20-9-18(11-25(33)39)10-21(12-20)41(28,29,30,31)32/h3-10,12-15H,11H2,1-2H3,(H2,33,39)(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239658 (US9394309, 114) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)C(C)(C)C)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C30H28N6O/c1-19-11-20(2)27(35-9-10-36-28(35)16-26(34-36)22-7-6-8-32-18-22)15-25(19)33-29(37)23-12-21(17-31)13-24(14-23)30(3,4)5/h6-16,18H,1-5H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239620 (US9394309, 73) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H20F5N5OS/c1-16-11-17(2)23(34-9-10-35-24(34)14-22(33-35)19-6-4-8-31-15-19)13-21(16)32-25(36)18-5-3-7-20(12-18)37(26,27,28,29)30/h3-15H,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239712 (US9394309, 171) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnn1 Show InChI InChI=1S/C25H18F5N7OS/c1-15-8-16(2)23(36-6-7-37-24(36)13-22(35-37)20-4-3-5-32-34-20)12-21(15)33-25(38)18-9-17(14-31)10-19(11-18)39(26,27,28,29)30/h3-13H,1-2H3,(H,33,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239595 (US9394309, 48) Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C33H37N7O/c1-23-8-9-27(20-30(23)39-15-16-40-31(39)21-29(36-40)24-7-6-10-34-22-24)35-32(41)25-17-26(33(2,3)4)19-28(18-25)38-13-11-37(5)12-14-38/h6-10,15-22H,11-14H2,1-5H3,(H,35,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239594 (US9394309, 47) Show SMILES Cc1nccn1-c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C32H31N7O/c1-21-8-9-26(18-29(21)38-13-14-39-30(38)19-28(36-39)23-7-6-10-33-20-23)35-31(40)24-15-25(32(3,4)5)17-27(16-24)37-12-11-34-22(37)2/h6-20H,1-5H3,(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239583 (US9394309, 36) Show SMILES CN1CCN(Cc2cc(cc(c2)S(F)(F)(F)(F)F)C(=O)Nc2ccc(C)c(c2)-n2ccn3nc(cc23)-c2cccnc2)CC1 Show InChI InChI=1S/C30H30F5N7OS/c1-21-5-6-25(17-28(21)41-12-13-42-29(41)18-27(38-42)23-4-3-7-36-19-23)37-30(43)24-14-22(20-40-10-8-39(2)9-11-40)15-26(16-24)44(31,32,33,34)35/h3-7,12-19H,8-11,20H2,1-2H3,(H,37,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239570 (US9394309, 23) Show SMILES Cc1ccc(NC(=O)c2cc(OCCCN)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H25F5N6O2S/c1-18-5-6-21(14-25(18)37-9-10-38-26(37)16-24(36-38)19-4-2-8-34-17-19)35-27(39)20-12-22(40-11-3-7-33)15-23(13-20)41(28,29,30,31)32/h2,4-6,8-10,12-17H,3,7,11,33H2,1H3,(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239564 (US9394309, 17) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCNCC2)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C28H26F5N7OS/c1-19-4-5-22(15-26(19)39-11-12-40-27(39)17-25(37-40)20-3-2-6-35-18-20)36-28(41)21-13-23(38-9-7-34-8-10-38)16-24(14-21)42(29,30,31,32)33/h2-6,11-18,34H,7-10H2,1H3,(H,36,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239558 (US9394309, 11) Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1cc(C)n2nc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C28H29F5N8OS/c1-18-4-5-22(12-26(18)40-17-19(2)41-27(40)14-25(37-41)21-15-34-35-16-21)36-28(42)20-10-23(39-8-6-38(3)7-9-39)13-24(11-20)43(29,30,31,32)33/h4-5,10-17H,6-9H2,1-3H3,(H,34,35)(H,36,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239557 (US9394309, 10) Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)S(F)(F)(F)(F)F)N3CCNCC3)ccc2C)c2cc(nn12)-c1cn[nH]c1 Show InChI InChI=1S/C27H27F5N8OS/c1-17-3-4-21(11-25(17)39-16-18(2)40-26(39)13-24(37-40)20-14-34-35-15-20)36-27(41)19-9-22(38-7-5-33-6-8-38)12-23(10-19)42(28,29,30,31)32/h3-4,9-16,33H,5-8H2,1-2H3,(H,34,35)(H,36,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239548 (US9394309, 1) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCNCC2)cc1-n1ccn2nc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C26H25F5N8OS/c1-17-2-3-20(12-24(17)38-8-9-39-25(38)14-23(36-39)19-15-33-34-16-19)35-26(40)18-10-21(37-6-4-32-5-7-37)13-22(11-18)41(27,28,29,30)31/h2-3,8-16,32H,4-7H2,1H3,(H,33,34)(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239706 (US9394309, 164) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cncnc1 Show InChI InChI=1S/C24H19F5N6OS/c1-15-8-16(2)22(34-6-7-35-23(34)11-21(33-35)18-12-30-14-31-13-18)10-20(15)32-24(36)17-4-3-5-19(9-17)37(25,26,27,28)29/h3-14H,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239561 (US9394309, 14) Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)C(F)(F)F)-n3ccnc3C)ccc2C)c2cc(nn12)-c1cn[nH]c1 Show InChI InChI=1S/C28H23F3N8O/c1-16-4-5-22(11-25(16)38-15-17(2)39-26(38)12-24(36-39)20-13-33-34-14-20)35-27(40)19-8-21(28(29,30)31)10-23(9-19)37-7-6-32-18(37)3/h4-15H,1-3H3,(H,33,34)(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239697 (US9394309, 154) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(C)(C)O)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H28F5N5O2S/c1-18-10-19(2)26(38-8-9-39-27(38)15-25(37-39)21-6-5-7-35-17-21)14-24(18)36-28(40)22-11-20(16-29(3,4)41)12-23(13-22)42(30,31,32,33)34/h5-15,17,41H,16H2,1-4H3,(H,36,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239661 (US9394309, 118) Show SMILES Cc1cc(F)c(NC(=O)c2cc(cc(c2)C(C)(C)C)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H25FN6O/c1-18-10-23(30)25(33-28(37)21-11-19(16-31)12-22(13-21)29(2,3)4)14-26(18)35-8-9-36-27(35)15-24(34-36)20-6-5-7-32-17-20/h5-15,17H,1-4H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239695 (US9394309, 152) Show SMILES COC(=O)Cc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C28H24F5N5O3S/c1-17-9-18(2)25(37-7-8-38-26(37)15-24(36-38)20-5-4-6-34-16-20)14-23(17)35-28(40)21-10-19(12-27(39)41-3)11-22(13-21)42(29,30,31,32)33/h4-11,13-16H,12H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239584 (US9394309, 37) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C2(O)CNC2)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H23F5N6O2S/c1-17-4-5-21(12-24(17)37-7-8-38-25(37)13-23(36-38)18-3-2-6-33-14-18)35-26(39)19-9-20(27(40)15-34-16-27)11-22(10-19)41(28,29,30,31)32/h2-14,34,40H,15-16H2,1H3,(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239691 (US9394309, 148) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C(C)(C)O)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C28H26F5N5O2S/c1-17-10-18(2)25(37-8-9-38-26(37)15-24(36-38)19-6-5-7-34-16-19)14-23(17)35-27(39)20-11-21(28(3,4)40)13-22(12-20)41(29,30,31,32)33/h5-16,40H,1-4H3,(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239579 (US9394309, 32) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H24F5N5O2S/c1-17-6-7-21(14-24(17)36-9-10-37-25(36)15-23(35-37)18-5-4-8-33-16-18)34-26(38)19-11-20(27(2,3)39)13-22(12-19)40(28,29,30,31)32/h4-16,39H,1-3H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM194837 (US9206184, 18 | US9206184, 19) Show SMILES CCOCc1c(CN2CCNCC2)n2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1 Show InChI InChI=1S/C24H30N6O2S/c1-4-32-13-17-18(12-29-7-5-26-6-8-29)30-22(24(25)27-14-28-30)21(17)20-11-16-9-15(2)10-19(31-3)23(16)33-20/h9-11,14,26H,4-8,12-13H2,1-3H3,(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
BAYER INTELLECTUAL PROPERTY GmbH US Patent					Assay Description For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...				US Patent US9206184 (2015) BindingDB Entry DOI: 10.7270/Q2SN07SH
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239683 (US9394309, 140) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)C1(C)COC1)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H27N5O2/c1-19-12-20(2)26(33-10-11-34-27(33)15-25(32-34)22-7-5-9-30-16-22)14-24(19)31-28(35)21-6-4-8-23(13-21)29(3)17-36-18-29/h4-16H,17-18H2,1-3H3,(H,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239653 (US9394309, 109) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Br)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H19BrF5N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM194880 (US9206184, 61) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(-c2cnco2)c(CN2CCNCC2)n2ncnc(N)c12 Show InChI InChI=1S/C24H25N7O2S/c1-14-7-15-9-19(34-23(15)17(8-14)32-2)21-20(18-10-27-13-33-18)16(11-30-5-3-26-4-6-30)31-22(21)24(25)28-12-29-31/h7-10,12-13,26H,3-6,11H2,1-2H3,(H2,25,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
BAYER INTELLECTUAL PROPERTY GmbH US Patent					Assay Description For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...				US Patent US9206184 (2015) BindingDB Entry DOI: 10.7270/Q2SN07SH
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239587 (US9394309, 40) Show SMILES Cc1nccn1-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H22F3N7O/c1-18-5-6-23(15-26(18)38-10-11-39-27(38)16-25(36-39)20-4-3-7-33-17-20)35-28(40)21-12-22(29(30,31)32)14-24(13-21)37-9-8-34-19(37)2/h3-17H,1-2H3,(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239660 (US9394309, 116) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(nc(c1)C(C)(C)C)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H27N7O/c1-18-11-19(2)25(35-9-10-36-27(35)15-24(34-36)20-7-6-8-31-17-20)14-23(18)33-28(37)21-12-22(16-30)32-26(13-21)29(3,4)5/h6-15,17H,1-5H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239621 (US9394309, 147 | US9394309, 74) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239582 (US9394309, 35) Show SMILES Cc1ccc(NC(=O)c2cc(CN3CCNCC3)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H28F5N7OS/c1-20-4-5-24(16-27(20)40-11-12-41-28(40)17-26(38-41)22-3-2-6-36-18-22)37-29(42)23-13-21(19-39-9-7-35-8-10-39)14-25(15-23)43(30,31,32,33)34/h2-6,11-18,35H,7-10,19H2,1H3,(H,37,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239682 (US9394309, 139) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)C(C)(C)C(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H26F3N5O/c1-18-13-19(2)25(36-11-12-37-26(36)16-24(35-37)21-8-6-10-33-17-21)15-23(18)34-27(38)20-7-5-9-22(14-20)28(3,4)29(30,31)32/h5-17H,1-4H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM194900 (US9206184, 81 | US9206184, 82) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(C)(C)O)c(Cl)n2ncnc(N)c12 Show InChI InChI=1S/C21H24ClN5O2S/c1-11-5-12-7-15(30-18(12)14(6-11)29-4)16-13(8-24-9-21(2,3)28)19(22)27-17(16)20(23)25-10-26-27/h5-7,10,24,28H,8-9H2,1-4H3,(H2,23,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
BAYER INTELLECTUAL PROPERTY GmbH US Patent					Assay Description For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...				US Patent US9206184 (2015) BindingDB Entry DOI: 10.7270/Q2SN07SH
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239700 (US9394309, 157) Show SMILES Cc1cc(Cl)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C24H17ClF5N5OS/c1-15-10-19(25)22(34-8-9-35-23(34)13-21(33-35)17-5-3-7-31-14-17)12-20(15)32-24(36)16-4-2-6-18(11-16)37(26,27,28,29)30/h2-14H,1H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239622 (US9394309, 75) Show SMILES Cc1cc(F)c(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H16F6N6OS/c1-15-7-20(26)22(34-25(38)18-8-16(13-32)9-19(10-18)39(27,28,29,30)31)11-23(15)36-5-6-37-24(36)12-21(35-37)17-3-2-4-33-14-17/h2-12,14H,1H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239657 (US9394309, 113) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Br)cc(c1)C(C)(C)C)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H28BrN5O/c1-18-11-19(2)26(34-9-10-35-27(34)16-25(33-35)20-7-6-8-31-17-20)15-24(18)32-28(36)21-12-22(29(3,4)5)14-23(30)13-21/h6-17H,1-5H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239651 (US9394309, 107) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(F)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H19F6N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239621 (US9394309, 147 | US9394309, 74) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	9.6	4
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239569 (US9394309, 22) Show SMILES Cc1ccc(NC(=O)c2cc(OCCN)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C26H23F5N6O2S/c1-17-4-5-20(13-24(17)36-8-9-37-25(36)15-23(35-37)18-3-2-7-33-16-18)34-26(38)19-11-21(39-10-6-32)14-22(12-19)40(27,28,29,30)31/h2-5,7-9,11-16H,6,10,32H2,1H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239551 (US9394309, 4) Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C25H23F5N6O2S/c1-15-4-5-19(11-22(15)35-6-7-36-23(35)12-21(34-36)17-13-31-32-14-17)33-24(37)16-8-18(25(2,3)38)10-20(9-16)39(26,27,28,29)30/h4-14,38H,1-3H3,(H,31,32)(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239687 (US9394309, 144) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)N1CCC(CC1)C#N)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C31H28F5N7OS/c1-20-12-21(2)29(42-10-11-43-30(42)17-28(40-43)23-4-3-7-38-19-23)16-27(20)39-31(44)24-13-25(41-8-5-22(18-37)6-9-41)15-26(14-24)45(32,33,34,35)36/h3-4,7,10-17,19,22H,5-6,8-9H2,1-2H3,(H,39,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239655 (US9394309, 111) Show SMILES Cc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C26H22F5N5OS/c1-16-9-20(12-21(10-16)38(27,28,29,30)31)26(37)33-22-13-24(18(3)11-17(22)2)35-7-8-36-25(35)14-23(34-36)19-5-4-6-32-15-19/h4-15H,1-3H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239559 (US9394309, 12) Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)S(F)(F)(F)(F)F)C#N)ccc2C)c2cc(nn12)-c1cn[nH]c1 Show InChI InChI=1S/C24H18F5N7OS/c1-14-3-4-19(33-24(37)17-5-16(10-30)6-20(7-17)38(25,26,27,28)29)8-22(14)35-13-15(2)36-23(35)9-21(34-36)18-11-31-32-12-18/h3-9,11-13H,1-2H3,(H,31,32)(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM194837 (US9206184, 18 | US9206184, 19) Show SMILES CCOCc1c(CN2CCNCC2)n2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1 Show InChI InChI=1S/C24H30N6O2S/c1-4-32-13-17-18(12-29-7-5-26-6-8-29)30-22(24(25)27-14-28-30)21(17)20-11-16-9-15(2)10-19(31-3)23(16)33-20/h9-11,14,26H,4-8,12-13H2,1-3H3,(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
BAYER INTELLECTUAL PROPERTY GmbH US Patent					Assay Description For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...				US Patent US9206184 (2015) BindingDB Entry DOI: 10.7270/Q2SN07SH
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239652 (US9394309, 108) Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Cl)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C25H19ClF5N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239565 (US9394309, 18) Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C29H28F5N7OS/c1-20-5-6-23(16-27(20)40-12-13-41-28(40)18-26(37-41)21-4-3-7-35-19-21)36-29(42)22-14-24(39-10-8-38(2)9-11-39)17-25(15-22)43(30,31,32,33)34/h3-7,12-19H,8-11H2,1-2H3,(H,36,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239656 (US9394309, 112) Show SMILES COCc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C27H24F5N5O2S/c1-17-9-18(2)25(36-7-8-37-26(36)14-24(35-37)20-5-4-6-33-15-20)13-23(17)34-27(38)21-10-19(16-39-3)11-22(12-21)40(28,29,30,31)32/h4-15H,16H2,1-3H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor [776-1124] (Homo sapiens (Human))	BDBM239598 (US9394309, 51) Show SMILES Cc1ccc(NC(=O)c2cc(CN3CCCC3)cc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1 Show InChI InChI=1S/C33H36N6O/c1-23-9-10-28(19-30(23)38-14-15-39-31(38)20-29(36-39)25-8-7-11-34-21-25)35-32(40)26-16-24(22-37-12-5-6-13-37)17-27(18-26)33(2,3)4/h7-11,14-21H,5-6,12-13,22H2,1-4H3,(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH US Patent					Assay Description For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...				US Patent US9394309 (2016) BindingDB Entry DOI: 10.7270/Q2C53JRC
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM194844 (US9206184, 25) Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC2CC2)c(CN2CCNCC2)n2ncnc(N)c12 Show InChI InChI=1S/C26H32N6O2S/c1-16-9-18-11-22(35-25(18)21(10-16)33-2)23-19(14-34-13-17-3-4-17)20(12-31-7-5-28-6-8-31)32-24(23)26(27)29-15-30-32/h9-11,15,17,28H,3-8,12-14H2,1-2H3,(H2,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.0	22
BAYER INTELLECTUAL PROPERTY GmbH US Patent					Assay Description For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...				US Patent US9206184 (2015) BindingDB Entry DOI: 10.7270/Q2SN07SH
					More data for this Ligand-Target Pair

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