| Reaction Details |
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 | Report a problem with these data |
| Target | Complement factor B |
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| Ligand | BDBM251886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 460±n/a nM |
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| Comments | extracted |
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| Citation |  Adams, CM; Babu, C; Capparelli, MP; Ding, J; Ehara, T; Jendza, K; Ji, N; Karki, RG; Kawanami, T; Xue, L; Mainolfi, N; Powers, JJ; Serrano-Wu, MH; Zhang, C Complement factor B inhibitors and uses there of US Patent US9475806 Publication Date 10/25/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement factor B |
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| Name: | Complement factor B |
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| Synonyms: | BF | BFD | CFAB_HUMAN | CFB |
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| Type: | Enzyme |
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| Mol. Mass.: | 85537.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00751 |
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| Residue: | 764 |
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| Sequence: | MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
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| BDBM251886 |
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| n/a |
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| Name | BDBM251886 |
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| Synonyms: | US9475806, 16-G |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17N5O |
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| Mol. Mass. | 343.3819 |
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| SMILES | Cc1cc(C2CC2)c(C(O)c2nc3cc(cnc3[nH]2)C#N)c2cc[nH]c12 |
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| Structure | 
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