| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 [397-806]/Glutathione S-transferase P |
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| Ligand | BDBM255637 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Based Assay |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 41.8±n/a nM |
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| Comments | extracted |
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| Citation |  Lobell, M; Hübsch, W; Schirok, H; Héroult, M; Brohm, D; Collin, M; Grünewald, S; Lustig, K; Bömer, U; Voehringer, V; Lindner, N Substituted benzothienyl-pyrrolotriazines and uses thereof US Patent US9475815 Publication Date 10/25/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 3 [397-806]/Glutathione S-transferase P |
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| Name: | Fibroblast growth factor receptor 3 [397-806]/Glutathione S-transferase P |
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| Synonyms: | GST-Fibroblast growth factor receptor 3 (FGFR-3) |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glutathione S-transferase P |
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| Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) |
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| Type: | Enzyme |
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| Mol. Mass.: | 23353.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09211 |
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| Residue: | 210 |
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| Sequence: | MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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| Component 2 |
| Name: | Fibroblast growth factor receptor 3 [397-806] |
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| Synonyms: | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45431.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22607[397-806] |
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| Residue: | 410 |
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| Sequence: | RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSE
LELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD
KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLD
YSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADF
GLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP
GIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS
TDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
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| BDBM255637 |
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| n/a |
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| Name | BDBM255637 |
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| Synonyms: | US9475815, 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N6O2S |
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| Mol. Mass. | 466.599 |
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| SMILES | COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC(C2)NCC(C)O)n2ncnc(N)c12 |
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| Structure | 
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