| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 [1-454] |
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| Ligand | BDBM150720 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Quench Assay |
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| pH | 4.4±n/a |
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| IC50 | 6±n/a nM |
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| Comments | extracted |
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| Citation |  Bukhtiyarov, Y; Cacatian, S; Dillard, LW; Dorner-Ciossek, C; Fuchs, K; Jia, L; Lala, DS; Morales-Ramos, A; Reeves, J; Singh, SB; Venkatraman, S; Xu, Z; Yuan, J; Zhao, Y; Zheng, Y; Rast, G Inhibitors of beta-secretase US Patent US9526727 Publication Date 12/27/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 1 [1-454] |
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| Name: | Beta-secretase 1 [1-454] |
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| Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE1) | KIAA1149 |
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| Type: | Protein |
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| Mol. Mass.: | 50294.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human BACE1 truncation (1-454 aa) |
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| Residue: | 454 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDEST
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| BDBM150720 |
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| n/a |
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| Name | BDBM150720 |
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| Synonyms: | US8981112, 27 | US9526727, 27 | US9949975, Example 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N4O4 |
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| Mol. Mass. | 438.5194 |
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| SMILES | CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@]22N=C(N)N(CC3COCCO3)C2=O)C#N)C[C@@H]1C |r,t:16| |
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| Structure | 
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