Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 11 |
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Ligand | BDBM408097 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SHP2 Allosteric Inhibition Assay |
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IC50 | 8.00±n/a nM |
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Citation | Chen, CH; Chen, Z; Dore, M; Fortanet, JG; Giraldes, JW; Karki, R; Kato, M; LaMarche, MJ; Perez, LB; Sendzik, M; Smith, TD; Toure, B; Williams, S N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2 US Patent US10336774 Publication Date 7/2/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 11 |
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Name: | Tyrosine-protein phosphatase non-receptor type 11 |
Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
Type: | Protein phosphatase |
Mol. Mass.: | 68443.59 |
Organism: | Homo sapiens (Human) |
Description: | Q06124 |
Residue: | 593 |
Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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BDBM408097 |
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n/a |
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Name | BDBM408097 |
Synonyms: | US10336774, Example 91 |
Type | Small organic molecule |
Emp. Form. | C18H23ClFN7S |
Mol. Mass. | 423.939 |
SMILES | N[C@@H]1C[C@H](F)CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1 |r| |
Structure |
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