| Reaction Details |
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 | Report a problem with these data |
| Target | Epithelial discoidin domain-containing receptor 1 |
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| Ligand | BDBM372044 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Binding Assay for DDR1 |
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| IC50 | 27.3±n/a nM |
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| Citation |  Buettelmann, B; Kocer, B; Kuhn, B; Prunotto, M; Richter, H; Ritter, M; Rudolph, M; Satz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent US10435407 Publication Date 10/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epithelial discoidin domain-containing receptor 1 |
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| Name: | Epithelial discoidin domain-containing receptor 1 |
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| Synonyms: | CAK | DDR1 | DDR1_HUMAN | Discoidin domain receptor 1 (DDR1) | Discoidin domain-containing receptor 1 (DDR1) | Discoidin receptor tyrosine kinase | EDDR1 | Epithelial discoidin domain receptor 1 | Epithelial discoidin domain receptor 1 (DDR1) | Epithelial discoidin domain-containing receptor 1 | Epithelial discoidin domain-containing receptor 1 (DDR1) | HGK2 | Mammary carcinoma kinase 10 | NEP | NTRK4 | PTK3A | Protein-tyrosine kinase RTK 6 | RTK6 | TRKE | Tyrosine-protein kinase CAK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 101130.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08345 |
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| Residue: | 913 |
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| Sequence: | MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT
QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP
PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD
ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED
KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI
KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC
RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
LHRFLAEDALNTV
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| BDBM372044 |
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| n/a |
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| Name | BDBM372044 |
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| Synonyms: | (RS)-3-[2-(3-Fluoro-3-methylpyrrolidin-1-yl)-2-oxoethyl]-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one | US10239876, Example 67 | US10435407, Example 67 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30FN7O3 |
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| Mol. Mass. | 519.5706 |
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| SMILES | CC1(F)CCN(C1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O |
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| Structure | 
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