| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Activin receptor type-1B |
|---|
| Ligand | BDBM423157 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Assay |
|---|
| IC50 | 13.0±n/a nM |
|---|
| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10501436 Publication Date 12/10/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Activin receptor type-1B |
|---|
| Name: | Activin receptor type-1B |
|---|
| Synonyms: | ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56810.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_587064 |
|---|
| Residue: | 505 |
|---|
| Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
|
|
|
|---|
| BDBM423157 |
|---|
| n/a |
|---|
| Name | BDBM423157 |
|---|
| Synonyms: | (S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-yl)pyridin-4-ylamino)-N-(1-hydroxypropan-2-yl)nicotinamide | US10501436, Compound 7a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22ClFN4O2 |
|---|
| Mol. Mass. | 440.898 |
|---|
| SMILES | CC=Cc1cnc(cc1Nc1ccncc1C(=O)N[C@@H](C)CO)-c1cc(Cl)ccc1F |w:1.0| |
|---|
| Structure | 
|
|---|
Search and Browse
