Reaction Details |
| Report a problem with these data |
Target | Tissue-type plasminogen activator |
---|
Ligand | BDBM298098 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Plasma-based Clot Lysis Assay |
---|
IC50 | 11.0±n/a nM |
---|
Citation | Ellermann, M; Valot, G; Cancho Grande, Y; Haßfeld, J; Kinzel, T; Köbberling, J; Beyer, K; Röhrig, S; Sperzel, M; Stampfuß, J; Meyer, I; Köllnberger, M; Burkhardt, N; Schlemmer, K; Stegmann, C; Schuhmacher, J; Werner, M; Heiermann, J; Hengeveld, WJ Piperidinylpyrazolopyrimidinones and their use US Patent US10118930 Publication Date 11/6/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tissue-type plasminogen activator |
---|
Name: | Tissue-type plasminogen activator |
Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
Type: | Enzyme |
Mol. Mass.: | 62931.08 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 562 |
Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
|
|
|
BDBM298098 |
---|
n/a |
---|
Name | BDBM298098 |
Synonyms: | 3-(4-ethyl-1,3-thiazol-2-yl)-7-(piperidin-4-yl)pyrazolo[1,5-a]pyrimidin-5(4H)-one hydrochloride | US10118930, Example 308 |
Type | Small organic molecule |
Emp. Form. | C16H19N5OS |
Mol. Mass. | 329.42 |
SMILES | CCc1csc(n1)-c1cnn2c(cc(=O)[nH]c12)C1CCNCC1 |
Structure |
|