Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456669

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.056±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456669

n/a

Name

BDBM456669

Synonyms:

US10736883, Example 116.0

Type

Small organic molecule

Emp. Form.

C23H25FN6O6S

Mol. Mass.

532.545

SMILES

CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1 |r,wU:3.3,2.1,(5.36,-4.06,;4.02,-3.29,;4.02,-1.75,;2.69,-.98,;2.69,.56,;1.35,-1.75,;.58,-3.09,;2.12,-3.09,;.02,-.98,;-1.44,-1.46,;-1.92,-2.93,;-3.46,-2.93,;-3.94,-1.46,;-5.4,-.98,;-5.88,.48,;-7.42,.48,;-7.89,-.98,;-9.36,-1.46,;-6.65,-1.89,;-2.69,-.56,;-2.69,.98,;-4.02,1.75,;-5.36,.98,;-6.69,1.75,;-4.02,3.29,;-2.69,4.06,;-1.36,3.29,;-1.36,1.75,;-.02,.98,;1.31,1.75,;5.36,-.98,;6.69,-1.75,;8.02,-.98,;8.02,.56,;9.36,1.33,;6.69,1.33,;5.36,.56,)|

Structure