| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
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| Ligand | BDBM127693 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | >1000±n/a nM |
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| Citation |  Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US10758542 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [808-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
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| Synonyms: | JAK2 | JAK2_HUMAN | Janus kinase 2 (JAK2) | Tyrosine-protein kinase JAK2 | Tyrosine-protein kinase JAK2 (808-1132) |
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| Type: | n/a |
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| Mol. Mass.: | 37984.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | 808-1132 aa of O60674 |
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| Residue: | 325 |
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| Sequence: | LFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCR
YDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKL
IMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL
FTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWN
NNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM127693 |
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| n/a |
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| Name | BDBM127693 |
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| Synonyms: | US10251889, Example 66 | US10758542, Example 66 | US8791123, 66 | US9782415, Example 66 | US9796724, Example 66 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F2N5O2 |
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| Mol. Mass. | 413.4205 |
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| SMILES | Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NOCC3CC3)c2n1 |r| |
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| Structure | 
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