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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] | ||
| Ligand | BDBM493090 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 1.60±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] | |||
| Name: | Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] | ||
| Synonyms: | TYK2 | TYK2 [aa 580-1182,C936A,C1142A] | TYK2_HUMAN | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 68154.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29597[aa 580-1182,C936A,C1142A] | ||
| Residue: | 603 | ||
| Sequence: |
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| BDBM493090 | |||
| n/a | |||
| Name | BDBM493090 | ||
| Synonyms: | N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)benzimidamide | US10981911, Example 30 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25N7 | ||
| Mol. Mass. | 411.5022 | ||
| SMILES | N=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 |r,wU:19.22,wD:16.18,(-2.79,4.17,;-3.56,2.83,;-2.79,1.5,;-1.25,1.5,;-.48,.17,;-1.11,-1.24,;.04,-2.27,;.04,-3.81,;1.37,-4.58,;2.7,-3.81,;4.17,-4.29,;5.07,-3.04,;4.17,-1.8,;2.7,-2.27,;1.37,-1.5,;1.05,0,;2.08,1.15,;3.59,.83,;4.62,1.97,;4.14,3.44,;5.17,4.58,;6.68,4.26,;8.18,3.94,;2.63,3.76,;1.6,2.61,;-5.1,2.83,;-5.87,4.17,;-7.41,4.17,;-8.18,2.83,;-7.41,1.5,;-5.87,1.5,)| | ||
| Structure | 
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