| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM494783 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 54.1±n/a nM |
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| Citation |  Liu, K; Achab, A; Biju, P; Cernak, TA; Deng, Y; Fradera, X; Guo, L; Han, Y; He, S; Kozlowski, J; Li, D; Li, G; Pu, Q; Shi, Z; Yu, W; Zhang, H Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors US Patent US10988487 Publication Date 4/27/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM494783 |
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| n/a |
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| Name | BDBM494783 |
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| Synonyms: | N~2~-(4-{N-[(1S)-6-fluoro- 2,3-dihydro-1H-inden-1-yl]- N'-hydroxycarbamimidoyl}- 1,2,5-oxadiazol-3-yl)-N-(2- hydroxypropyl)glycinamide | US10988487, Example 179 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21FN6O4 |
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| Mol. Mass. | 392.3848 |
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| SMILES | CC(O)CNC(=O)CNc1nonc1\C(N[C@H]1CCc2ccc(F)cc12)=N\O |r| |
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| Structure | 
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