Affinity DataKi: 0.00600nMAssay Description:Inhibition of EGFRChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Inhibition of binding of [3H][D-Ala2,D-Leu5]enkephalin to Opioid receptor delta 1 in the rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2HH6MZQPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2HH6MZQPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataKi: 0.100nMAssay Description:Inhibition of wild-type EGFR (unknown origin) by high-throughput biochemical screeningMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2XK8H5BPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2XK8H5BPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataKi: 0.100nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR catalytic domain (669 to 1210 residues) expressed in baculovirus expression system by mass...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q25T3NCCPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q25T3NCCPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataKi: 0.140nMAssay Description:Inhibition of PF-06422899 binding to EGFR in human A431 cells after 1 hr by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
Affinity DataKi: 0.350nMAssay Description:Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin incubated ...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2R49RR6PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2R49RR6PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataKi: >0.530nMAssay Description:Inhibition of human wild type EGFR using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins followed by addition of substrate measured afte...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
Ligand Info
In DepthDetails
Affinity DataKi: 0.600nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
Ligand Info
In DepthDetails
Ligand Info
In DepthDetails
Affinity DataKi: 1.10nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDB
Ligand Info
In DepthDetails
Ligand Info
In DepthDetails
Ligand InfoPDB
Affinity DataKi: 1.5nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataKi: 1.60nMAssay Description:Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin incubated ...More data for this Ligand-Target Pair
Ligand InfoPDB
Ligand Info
In DepthDetails
Affinity DataKi: 2nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
Ligand Info
In DepthDetails
Affinity DataKi: 2nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Centre de Recherches
Curated by ChEMBL
Centre de Recherches
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2ZG6WHWPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2ZG6WHWPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant EGFR by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDB
Ligand Info
In DepthDetails
Affinity DataKi: 3.5nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDB
Affinity DataKi: 4nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
Ligand InfoPDB
Ligand Info
In DepthDetails
Affinity DataKi: 5.10nMAssay Description:Reversible inhibition of wild-type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
Ligand Info
In DepthDetails
Affinity DataKi: 6nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair