Found 7849 hits for UniProtKB: P37231 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085048
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)Show SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1 Show InChI InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
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Similars
| PDB
Article
PubMed
| 0.0497 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sahmyook University
Curated by ChEMBL
| Assay Description
Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assay |
J Med Chem 60: 7459-7475 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00805
BindingDB Entry DOI: 10.7270/Q2XK8HQH |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50304633
(9-(5'-Cyclobutylaminocarbonyl-4'-thio-beta-D-ribof...)Show SMILES O[C@H]1[C@@H](O)[C@@H](S[C@@H]1C(=O)NC1CCC1)n1cnc2c(NCc3cccc(I)c3)ncnc12 |r| Show InChI InChI=1S/C21H23IN6O3S/c22-12-4-1-3-11(7-12)8-23-18-14-19(25-9-24-18)28(10-26-14)21-16(30)15(29)17(32-21)20(31)27-13-5-2-6-13/h1,3-4,7,9-10,13,15-17,21,29-30H,2,5-6,8H2,(H,27,31)(H,23,24,25)/t15-,16+,17-,21+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sahmyook University
Curated by ChEMBL
| Assay Description
Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assay |
J Med Chem 60: 7459-7475 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00805
BindingDB Entry DOI: 10.7270/Q2XK8HQH |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50287729
(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)Show SMILES CN(CCOc1ccc(CC(Oc2ccccc2)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C25H24N2O5/c1-27(25-26-21-9-5-6-10-22(21)32-25)15-16-30-19-13-11-18(12-14-19)17-23(24(28)29)31-20-7-3-2-4-8-20/h2-14,23H,15-17H2,1H3,(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
inhibition of [125I]-SB 236636 binding to human PPAR gamma receptor |
Bioorg Med Chem Lett 6: 2121-2126 (1996)
Article DOI: 10.1016/0960-894X(96)00383-6
BindingDB Entry DOI: 10.7270/Q2NS0TW1 |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085048
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)Show SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1 Show InChI InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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| Purchase
CHEMBL
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PC cid
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UniChem
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| PDB
Article
PubMed
| 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PPARgamma (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028
BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471981
(CHEMBL446629)Show SMILES Cn1cc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H31N3O4/c1-37-23-31(25-10-4-2-5-11-25)36-32(37)20-21-41-27-18-16-24(17-19-27)22-30(34(39)40)35-29-15-9-8-14-28(29)33(38)26-12-6-3-7-13-26/h2-19,23,30,35H,20-22H2,1H3,(H,39,40)/t30-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.692 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471983
(CHEMBL149876)Show SMILES Cc1sc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)N1CCOCC1 Show InChI InChI=1S/C32H33N3O5S/c1-22-27(34-32(41-22)35-16-19-39-20-17-35)15-18-40-25-13-11-23(12-14-25)21-29(31(37)38)33-28-10-6-5-9-26(28)30(36)24-7-3-2-4-8-24/h2-14,29,33H,15-21H2,1H3,(H,37,38)/t29-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.776 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471980
(CHEMBL147095)Show SMILES Cc1ccc(s1)-c1nc(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)c(C)o1 Show InChI InChI=1S/C33H30N2O5S/c1-21-12-17-30(41-21)32-35-27(22(2)40-32)18-19-39-25-15-13-23(14-16-25)20-29(33(37)38)34-28-11-7-6-10-26(28)31(36)24-8-4-3-5-9-24/h3-17,29,34H,18-20H2,1-2H3,(H,37,38)/t29-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471978
(CHEMBL147090)Show SMILES Cc1sc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccncc1 Show InChI InChI=1S/C33H29N3O4S/c1-22-28(36-32(41-22)25-15-18-34-19-16-25)17-20-40-26-13-11-23(12-14-26)21-30(33(38)39)35-29-10-6-5-9-27(29)31(37)24-7-3-2-4-8-24/h2-16,18-19,30,35H,17,20-21H2,1H3,(H,38,39)/t30-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.871 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471951
(CHEMBL343210)Show SMILES Cc1cc(no1)-c1nc(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)c(C)s1 Show InChI InChI=1S/C32H29N3O5S/c1-20-18-28(35-40-20)31-34-26(21(2)41-31)16-17-39-24-14-12-22(13-15-24)19-29(32(37)38)33-27-11-7-6-10-25(27)30(36)23-8-4-3-5-9-23/h3-15,18,29,33H,16-17,19H2,1-2H3,(H,37,38)/t29-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.891 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472023
(CHEMBL148384)Show SMILES Cc1oc(nc1CCOc1ccc(CC(Nc2ccccc2C(=O)c2cccnc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C33H29N3O5/c1-22-28(36-32(41-22)24-8-3-2-4-9-24)17-19-40-26-15-13-23(14-16-26)20-30(33(38)39)35-29-12-6-5-11-27(29)31(37)25-10-7-18-34-21-25/h2-16,18,21,30,35H,17,19-20H2,1H3,(H,38,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.933 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471959
(CHEMBL146301)Show SMILES Cc1sc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)N1CCN(CC1)C(=O)OC(C)(C)C Show InChI InChI=1S/C37H42N4O6S/c1-25-30(39-35(48-25)40-19-21-41(22-20-40)36(45)47-37(2,3)4)18-23-46-28-16-14-26(15-17-28)24-32(34(43)44)38-31-13-9-8-12-29(31)33(42)27-10-6-5-7-11-27/h5-17,32,38H,18-24H2,1-4H3,(H,43,44)/t32-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.977 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472019
(CHEMBL148668)Show SMILES CC(C)OC(=O)c1ccccc1NC(Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C31H32N2O6/c1-20(2)38-31(36)25-11-7-8-12-27(25)32-28(30(34)35)19-22-13-15-24(16-14-22)37-18-17-26-21(3)39-29(33-26)23-9-5-4-6-10-23/h4-16,20,28,32H,17-19H2,1-3H3,(H,34,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.977 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085048
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)Show SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1 Show InChI InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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| Purchase
CHEMBL
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| PDB
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50151001
((S)-2-((Z)-1-Methyl-3-oxo-3-phenyl-propenylamino)-...)Show SMILES CC(CC(=O)c1ccccc1)=N[C@@H](Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)C(O)=O |w:1.0| Show InChI InChI=1S/C31H30N2O5/c1-21(19-29(34)24-9-5-3-6-10-24)32-28(31(35)36)20-23-13-15-26(16-14-23)37-18-17-27-22(2)38-30(33-27)25-11-7-4-8-12-25/h3-16,28H,17-20H2,1-2H3,(H,35,36)/t28-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity for human peroxisome proliferator activated receptor gamma |
J Med Chem 47: 4118-27 (2004)
Article DOI: 10.1021/jm030631e
BindingDB Entry DOI: 10.7270/Q2DR2TZ5 |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085048
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)Show SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1 Show InChI InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| Purchase
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KEGG
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| PDB
Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116564
BindingDB Entry DOI: 10.7270/Q29G5RSJ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471968
(CHEMBL358379)Show SMILES Cc1sc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H30N2O4S/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085044
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
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antibodypedia
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| Purchase
CHEMBL
MCE
MMDB
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PDB
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| MMDB
PDB
Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa... |
J Med Chem 41: 5020-36 (1999)
Checked by Author
Article DOI: 10.1021/jm9804127
BindingDB Entry DOI: 10.7270/Q20K2B28 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085044
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
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Patents
Similars
| MMDB
PDB
Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471953
(CHEMBL356382)Show SMILES COc1ccc(cc1)-c1nc(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)c(C)o1 Show InChI InChI=1S/C35H32N2O6/c1-23-30(37-34(43-23)26-14-18-27(41-2)19-15-26)20-21-42-28-16-12-24(13-17-28)22-32(35(39)40)36-31-11-7-6-10-29(31)33(38)25-8-4-3-5-9-25/h3-19,32,36H,20-22H2,1-2H3,(H,39,40)/t32-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085044
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assay |
Bioorg Med Chem Lett 11: 3111-3 (2001)
BindingDB Entry DOI: 10.7270/Q2B27TKM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085044
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471966
(CHEMBL147935)Show SMILES Cc1cc(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)nn1-c1ccccc1 Show InChI InChI=1S/C34H31N3O4/c1-24-22-27(36-37(24)28-12-6-3-7-13-28)20-21-41-29-18-16-25(17-19-29)23-32(34(39)40)35-31-15-9-8-14-30(31)33(38)26-10-4-2-5-11-26/h2-19,22,32,35H,20-21,23H2,1H3,(H,39,40)/t32-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471974
(CHEMBL148950)Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccncc1 Show InChI InChI=1S/C33H29N3O5/c1-22-28(36-32(41-22)25-15-18-34-19-16-25)17-20-40-26-13-11-23(12-14-26)21-30(33(38)39)35-29-10-6-5-9-27(29)31(37)24-7-3-2-4-8-24/h2-16,18-19,30,35H,17,20-21H2,1H3,(H,38,39)/t30-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472043
(CHEMBL148596)Show SMILES CN(CCOc1ccc(CC(Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C32H29N3O5/c1-35(32-34-27-13-7-8-14-29(27)40-32)19-20-39-24-17-15-22(16-18-24)21-28(31(37)38)33-26-12-6-5-11-25(26)30(36)23-9-3-2-4-10-23/h2-18,28,33H,19-21H2,1H3,(H,37,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50418564
(CHEMBL423026)Show SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C32H29N3O5/c1-35(32-34-27-13-7-8-14-29(27)40-32)19-20-39-24-17-15-22(16-18-24)21-28(31(37)38)33-26-12-6-5-11-25(26)30(36)23-9-3-2-4-10-23/h2-18,28,33H,19-21H2,1H3,(H,37,38)/t28-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa... |
J Med Chem 41: 5020-36 (1999)
Checked by Author
Article DOI: 10.1021/jm9804127
BindingDB Entry DOI: 10.7270/Q20K2B28 |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472035
(CHEMBL2112870)Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)C2CCCCC2)C(O)=O)cc1)-c1ccccc1 |r| Show InChI InChI=1S/C34H36N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h3,6-9,12-19,25,31,35H,2,4-5,10-11,20-22H2,1H3,(H,38,39)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471982
(CHEMBL147384)Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H29FN2O5/c1-22-29(37-33(42-22)25-13-15-26(35)16-14-25)19-20-41-27-17-11-23(12-18-27)21-31(34(39)40)36-30-10-6-5-9-28(30)32(38)24-7-3-2-4-8-24/h2-18,31,36H,19-21H2,1H3,(H,39,40)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472034
(CHEMBL147021)Show SMILES COc1ccccc1C(=O)c1ccccc1NC(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C33H31N3O6/c1-36(33-35-27-12-6-8-14-30(27)42-33)19-20-41-23-17-15-22(16-18-23)21-28(32(38)39)34-26-11-5-3-9-24(26)31(37)25-10-4-7-13-29(25)40-2/h3-18,28,34H,19-21H2,1-2H3,(H,38,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50304639
(9-(5'-Cyclopropylmethylaminocarbonyl-4'-thio-beta-...)Show SMILES O[C@H]1[C@@H](O)[C@@H](S[C@@H]1C(=O)NCC1CC1)n1cnc2c(NCc3cccc(I)c3)ncnc12 |r| Show InChI InChI=1S/C21H23IN6O3S/c22-13-3-1-2-12(6-13)8-23-18-14-19(26-9-25-18)28(10-27-14)21-16(30)15(29)17(32-21)20(31)24-7-11-4-5-11/h1-3,6,9-11,15-17,21,29-30H,4-5,7-8H2,(H,24,31)(H,23,25,26)/t15-,16+,17-,21+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sahmyook University
Curated by ChEMBL
| Assay Description
Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assay |
J Med Chem 60: 7459-7475 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00805
BindingDB Entry DOI: 10.7270/Q2XK8HQH |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471955
(CHEMBL148797)Show SMILES Cc1cc(nn1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H31N3O4/c1-24-22-31(26-10-4-2-5-11-26)36-37(24)20-21-41-28-18-16-25(17-19-28)23-32(34(39)40)35-30-15-9-8-14-29(30)33(38)27-12-6-3-7-13-27/h2-19,22,32,35H,20-21,23H2,1H3,(H,39,40)/t32-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472037
(CHEMBL414442)Show SMILES Cc1oc(nc1CCOc1ccc(CC(Nc2ccccc2C(=O)c2ccncc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C33H29N3O5/c1-22-28(36-32(41-22)25-7-3-2-4-8-25)17-20-40-26-13-11-23(12-14-26)21-30(33(38)39)35-29-10-6-5-9-27(29)31(37)24-15-18-34-19-16-24/h2-16,18-19,30,35H,17,20-21H2,1H3,(H,38,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471970
(CHEMBL148459)Show SMILES Cc1ccsc1-c1nc(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)c(C)o1 Show InChI InChI=1S/C33H30N2O5S/c1-21-17-19-41-31(21)32-35-27(22(2)40-32)16-18-39-25-14-12-23(13-15-25)20-29(33(37)38)34-28-11-7-6-10-26(28)30(36)24-8-4-3-5-9-24/h3-15,17,19,29,34H,16,18,20H2,1-2H3,(H,37,38)/t29-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471948
(CHEMBL149647)Show SMILES COCn1c(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)c(C)nc1-c1ccccc1 Show InChI InChI=1S/C36H35N3O5/c1-25-33(39(24-43-2)35(37-25)28-13-7-4-8-14-28)21-22-44-29-19-17-26(18-20-29)23-32(36(41)42)38-31-16-10-9-15-30(31)34(40)27-11-5-3-6-12-27/h3-20,32,38H,21-24H2,1-2H3,(H,41,42)/t32-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085048
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)Show SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1 Show InChI InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| PDB
Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jnatprod.2c00791
BindingDB Entry DOI: 10.7270/Q2G44VDK |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471954
(CHEMBL358325)Show SMILES CN1CCN(CC1)c1nc(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)c(C)s1 Show InChI InChI=1S/C33H36N4O4S/c1-23-28(35-33(42-23)37-19-17-36(2)18-20-37)16-21-41-26-14-12-24(13-15-26)22-30(32(39)40)34-29-11-7-6-10-27(29)31(38)25-8-4-3-5-9-25/h3-15,30,34H,16-22H2,1-2H3,(H,39,40)/t30-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472047
(CHEMBL146355)Show SMILES CN(CCOc1ccc(CC(Nc2ccccc2C(=O)c2ccccc2C)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C33H31N3O5/c1-22-9-3-4-10-25(22)31(37)26-11-5-6-12-27(26)34-29(32(38)39)21-23-15-17-24(18-16-23)40-20-19-36(2)33-35-28-13-7-8-14-30(28)41-33/h3-18,29,34H,19-21H2,1-2H3,(H,38,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM21221
((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)Show SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 Show InChI InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
MCE
PC cid
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| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sahmyook University
Curated by ChEMBL
| Assay Description
Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assay |
J Med Chem 60: 7459-7475 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00805
BindingDB Entry DOI: 10.7270/Q2XK8HQH |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472048
(CHEMBL146562)Show SMILES CN(CCOc1ccc(CC(Nc2ccccc2C(=O)c2ccsc2)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C30H27N3O5S/c1-33(30-32-25-8-4-5-9-27(25)38-30)15-16-37-22-12-10-20(11-13-22)18-26(29(35)36)31-24-7-3-2-6-23(24)28(34)21-14-17-39-19-21/h2-14,17,19,26,31H,15-16,18H2,1H3,(H,35,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472024
(CHEMBL145886)Show SMILES COc1cccc(c1)C(=O)c1ccccc1NC(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C33H31N3O6/c1-36(33-35-28-12-5-6-13-30(28)42-33)18-19-41-24-16-14-22(15-17-24)20-29(32(38)39)34-27-11-4-3-10-26(27)31(37)23-8-7-9-25(21-23)40-2/h3-17,21,29,34H,18-20H2,1-2H3,(H,38,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50124394
(2-Methyl-2-{4-[4-(3-phenyl-7-propyl-benzo[d]isoxaz...)Show SMILES CCCc1c(OCCCCOc2ccc(OC(C)(C)C(O)=O)cc2)ccc2c(noc12)-c1ccccc1 Show InChI InChI=1S/C30H33NO6/c1-4-10-24-26(18-17-25-27(31-37-28(24)25)21-11-6-5-7-12-21)35-20-9-8-19-34-22-13-15-23(16-14-22)36-30(2,3)29(32)33/h5-7,11-18H,4,8-10,19-20H2,1-3H3,(H,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) |
Bioorg Med Chem Lett 13: 931-5 (2003)
BindingDB Entry DOI: 10.7270/Q2HX1C1Z |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472041
(CHEMBL147770)Show SMILES CCCOC(=O)c1ccccc1NC(Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C31H32N2O6/c1-3-18-38-31(36)25-11-7-8-12-27(25)32-28(30(34)35)20-22-13-15-24(16-14-22)37-19-17-26-21(2)39-29(33-26)23-9-5-4-6-10-23/h4-16,28,32H,3,17-20H2,1-2H3,(H,34,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085043
(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)Show SMILES CCOC(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C21H24N2O5/c1-3-26-19(20(24)25)14-15-8-10-16(11-9-15)27-13-12-23(2)21-22-17-6-4-5-7-18(17)28-21/h4-11,19H,3,12-14H2,1-2H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-SB 236636 binding to human PPAR gamma receptor |
Bioorg Med Chem Lett 6: 2127-2130 (1996)
Article DOI: 10.1016/0960-894X(96)00382-4
BindingDB Entry DOI: 10.7270/Q2J1034Z |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085043
(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)Show SMILES CCOC(Cc1ccc(OCCN(C)c2nc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C21H24N2O5/c1-3-26-19(20(24)25)14-15-8-10-16(11-9-15)27-13-12-23(2)21-22-17-6-4-5-7-18(17)28-21/h4-11,19H,3,12-14H2,1-2H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
inhibition of [125I]-SB 236636 binding to human PPAR gamma receptor |
Bioorg Med Chem Lett 6: 2121-2126 (1996)
Article DOI: 10.1016/0960-894X(96)00383-6
BindingDB Entry DOI: 10.7270/Q2NS0TW1 |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471989
(CHEMBL149835)Show SMILES Cc1[nH]c(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1 Show InChI InChI=1S/C34H31N3O4/c1-23-29(37-33(35-23)26-12-6-3-7-13-26)20-21-41-27-18-16-24(17-19-27)22-31(34(39)40)36-30-15-9-8-14-28(30)32(38)25-10-4-2-5-11-25/h2-19,31,36H,20-22H2,1H3,(H,35,37)(H,39,40)/t31-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472029
(CHEMBL149780)Show SMILES CN(CCOc1ccc(CC(Nc2cscc2C(=O)c2ccccc2)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C30H27N3O5S/c1-33(30-32-24-9-5-6-10-27(24)38-30)15-16-37-22-13-11-20(12-14-22)17-25(29(35)36)31-26-19-39-18-23(26)28(34)21-7-3-2-4-8-21/h2-14,18-19,25,31H,15-17H2,1H3,(H,35,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472021
(CHEMBL146637)Show SMILES CN(CCOc1ccc(CC(Nc2ccccc2C(=O)c2cccc(c2)C(F)(F)F)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C33H28F3N3O5/c1-39(32-38-27-11-4-5-12-29(27)44-32)17-18-43-24-15-13-21(14-16-24)19-28(31(41)42)37-26-10-3-2-9-25(26)30(40)22-7-6-8-23(20-22)33(34,35)36/h2-16,20,28,37H,17-19H2,1H3,(H,41,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471963
(CHEMBL359285)Show SMILES COCCNc1nc(CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c3ccccc3)C(O)=O)cc2)c(C)s1 Show InChI InChI=1S/C31H33N3O5S/c1-21-26(34-31(40-21)32-17-19-38-2)16-18-39-24-14-12-22(13-15-24)20-28(30(36)37)33-27-11-7-6-10-25(27)29(35)23-8-4-3-5-9-23/h3-15,28,33H,16-20H2,1-2H3,(H,32,34)(H,36,37)/t28-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50471991
(CHEMBL146650)Show SMILES Cc1sc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)N1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C33H36N4O6S2/c1-23-28(35-33(44-23)36-17-19-37(20-18-36)45(2,41)42)16-21-43-26-14-12-24(13-15-26)22-30(32(39)40)34-29-11-7-6-10-27(29)31(38)25-8-4-3-5-9-25/h3-15,30,34H,16-22H2,1-2H3,(H,39,40)/t30-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma |
J Med Chem 41: 5037-54 (1998)
Article DOI: 10.1021/jm980413z
BindingDB Entry DOI: 10.7270/Q2J38W9F |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472031
(CHEMBL146579)Show SMILES CN(CCOc1ccc(CC(Nc2ccccc2C(=O)c2ccccc2C(F)(F)F)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C33H28F3N3O5/c1-39(32-38-27-12-6-7-13-29(27)44-32)18-19-43-22-16-14-21(15-17-22)20-28(31(41)42)37-26-11-5-3-9-24(26)30(40)23-8-2-4-10-25(23)33(34,35)36/h2-17,28,37H,18-20H2,1H3,(H,41,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50472028
(CHEMBL150215)Show SMILES CN(CCOc1ccc(CC(Nc2ccccc2C(=O)c2cccc(C)c2)C(O)=O)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C33H31N3O5/c1-22-8-7-9-24(20-22)31(37)26-10-3-4-11-27(26)34-29(32(38)39)21-23-14-16-25(17-15-23)40-19-18-36(2)33-35-28-12-5-6-13-30(28)41-33/h3-17,20,29,34H,18-19,21H2,1-2H3,(H,38,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma) |
J Med Chem 41: 5055-69 (1998)
Article DOI: 10.1021/jm980414r
BindingDB Entry DOI: 10.7270/Q2DB84MJ |
More data for this
Ligand-Target Pair | |
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