The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28186757 |
66 |
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. |
European Institute of Oncology |
| 28186755 |
85 |
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration. |
European Institute of Oncology |
| 27888721 |
14 |
Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. |
Xinxiang Medical University |
| 28435523 |
9 |
Discovery of [1,2,3]Triazolo[4,5- |
Key Laboratory of Technology of Drug Preparation (Zhengzhou University) |
| 28065500 |
8 |
Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker. |
Nagoya City University |
| 27046190 |
10 |
Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design. |
Tu Dortmund University |
| 27105028 |
1 |
Efficient synthesis of new antiproliferative steroidal hybrids using the molecular hybridization approach. |
Zhengzhou University |
| 26710088 |
248 |
Recent Progress in Histone Demethylase Inhibitors. |
University of Oxford |
| 26819657 |
8 |
Cyclopropanamine Compounds and Use Thereof. |
Temple University |
| 26700437 |
32 |
Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators. |
Kyoto Prefectural University of Medicine |
| 26794039 |
12 |
Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide. |
Waseda University |
| 26652247 |
60 |
3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. |
Baylor College of Medicine |
| 26086931 |
38 |
Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators. |
Shandong University |
| 25699146 |
13 |
Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. |
Sapienza University of Rome |
| 25768700 |
30 |
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts. |
Sapienza University of Rome |
| 25610955 |
53 |
Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents. |
Zhengzhou University |
| 25827526 |
33 |
Histone H3 peptide based LSD1-selective inhibitors. |
Waseda University |
| 25725609 |
18 |
Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. |
John Hopkins University |
| 25173853 |
50 |
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. |
European Institute of Oncology |
| 24883177 |
10 |
Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. |
Medical University of South Carolina |
| 24237195 |
46 |
High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors. |
University of Utah |
| 24131029 |
90 |
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration. |
Zhengzhou University |
| 24007511 |
10 |
Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity. |
University of Freiburg |
| 22876979 |
2 |
Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1. |
Wayne State University |
| 22975593 |
62 |
Oncoepigenomics: making histone lysine methylation count. |
TBA |
| 20568780 |
2 |
(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators. |
Wayne State University |
| 21955276 |
60 |
Lysine demethylases inhibitors. |
Kyoto Prefectural University of Medicine |
| 21596573 |
46 |
Inhibitors of histone demethylases. |
University of Copenhagen |
| 21382717 |
19 |
Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors. |
University of Southampton |
| 21227703 |
3 |
Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. |
Nagoya City University |
| 32551003 |
53 |
Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors. |
Constellation Pharmaceuticals |
| 32201021 |
15 |
4-Hydroxy-3-methylbenzofuran-2-carbohydrazones as novel LSD1 inhibitors. |
Liaocheng University |
| 32435381 |
33 |
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. |
European Institute of Oncology Irccs |
| 32435375 |
22 |
New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes. |
Universidad San Pablo-Ceu |
| 27524309 |
62 |
Synthesis and biological evaluation of novel (E)-N'-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides as potent LSD1 inhibitors. |
Sichuan University |
| 30739825 |
32 |
Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors. |
Zhengzhou University |
| 31096156 |
55 |
Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors. |
Zhengzhou University |
| 30780087 |
32 |
Synthesis, structure-activity relationship studies and biological characterization of new [1,2,4]triazolo[1,5-a]pyrimidine-based LSD1/KDM1A inhibitors. |
Zhengzhou University |
| 30713023 |
51 |
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor. |
Liaoning Shihua University |
| 30611617 |
15 |
Identification of selective and reversible LSD1 inhibitors with anti-metastasis activity by high-throughput docking. |
Taizhou People'S Hospital |
| 30472603 |
11 |
Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors. |
Zhengzhou University |
| 30850265 |
6 |
Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma. |
West Virginia University |
| 31627991 |
35 |
Design, synthesis and biological evaluation of curcumin analogues as novel LSD1 inhibitors. |
Shenyang Pharmaceutical University |
| 30552007 |
18 |
Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro. |
China Pharmaceutical University |
| 30448189 |
28 |
Design, synthesis and in vitro evaluation of stilbene derivatives as novel LSD1 inhibitors for AML therapy. |
Xinxiang Medical University |
| 30409536 |
50 |
Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors. |
Celgene |
| 25580204 |
10 |
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. |
Medical University of South Carolina |
| 23293738 |
2 |
Polyamine-based small molecule epigenetic modulators. |
Wayne State University |
| 24325601 |
74 |
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. |
Sapienza University of Rome |
| 19534534 |
3 |
Recent advances in the development of polyamine analogues as antitumor agents. |
Johns Hopkins University |
| 29247860 |
80 |
Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation. |
University of Freiburg |
| 30153955 |
20 |
Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia. |
Fudan University |
| 29627262 |
109 |
Structure-based design and discovery of potent and selective KDM5 inhibitors. |
Celgene |
| 29496367 |
6 |
Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors. |
Alma Mater Studiorum-University of Bologna |
| 29439916 |
1 |
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. |
University of Nevada |
| 29331452 |
9 |
Design, synthesis and evaluation of ?-turn mimetics as LSD1-selective inhibitors. |
Kyoto Prefectural University of Medicine |
| 29198865 |
9 |
Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors. |
Waseda University |
| 29037950 |
21 |
Discovery of tranylcypromine analogs with an acylhydrazone substituent as LSD1 inactivators: Design, synthesis and their biological evaluation. |
Zhengzhou University |
| 29152043 |
6 |
Lysine-Specific Demethylase 1 (LSD1) Inhibitors as Potential Treatment for Different Types of Cancers. |
Therachem Research Medilab (India) |
| 29031059 |
61 |
Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors. |
East China Normal University |
| 28987602 |
38 |
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment. |
Xinxiang Medical University |
| 28927796 |
42 |
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1. |
University of Manchester |
| 27769034 |
36 |
Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors. |
Zhengzhou University |
| 28390942 |
27 |
Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A). |
University of East Anglia |
| 28610981 |
66 |
3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors. |
Zhengzhou University |
| 28512031 |
65 |
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. |
Genentech |
| 28545974 |
70 |
Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1. |
University of Manchester |
| 28892629 |
74 |
Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. |
University of Manchester |
| 28336409 |
14 |
Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. |
Nagoya City University |
| 21985377 |
42 |
Synthesis and biological evaluation of novel N, N'-disubstituted urea and thiourea derivatives as potential anti-melanoma agents. |
Nanjing University |
| 28481076 |
7 |
Heme Proximal Hydrogen Bonding between His170 and Asp132 Plays an Essential Role in the Heme Degradation Reaction of HutZ from Vibrio cholerae. |
Hokkaido University |
| 27595327 |
8 |
Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain. |
Oncology Innovative Medicines Unit |
| 11093776 |
5 |
Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. |
University of Alabama At Birmingham |
| 11093768 |
5 |
Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists. |
Pfizer |
| 10224099 |
14 |
Structural elements of the gamma-aminobutyric acid type A receptor conferring subtype selectivity for benzodiazepine site ligands. |
SynthÉLabo |
| 18972510 |
6 |
Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. |
Research Institute, Hospital For Sick Children |
| 7815359 |
29 |
Characterization of the cloned human mu opioid receptor. |
University of Pennsylvania |
| 3014519 |
39 |
Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. |
Merck Sharp & Dohme Research Laboratories |
| 19243944 |
35 |
Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors. |
Japan Tobacco |
| 18266313 |
30 |
A Structure-Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are delta/mu Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists. |
University of Arizona Tucson |
| 16876402 |
81 |
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. |
Gnf |
| 17254783 |
30 |
Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity. |
Karo Bio |
| 15582453 |
3 |
Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs. |
Crefsip |
| 17034121 |
20 |
Acylguanidines as small-molecule beta-secretase inhibitors. |
Wyeth Research |
| 16854060 |
58 |
Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). |
Universite De Montreal At Succursale Centre-Ville |
| 15658855 |
19 |
Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. |
Astex |
| 8676338 |
16 |
Time-dependent inactivation of aromatase by 6-alkylandrosta-1,4-diene-3,17-diones. Effects of length and configuration of 6-alkyl group. |
Tohoku College of Pharmacy |
| 12951118 |
24 |
HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent. |
Merck Research Laboratories |
| 12941332 |
27 |
6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3). |
Glaxosmithkline |
| 12941338 |
18 |
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. |
University of Newcastle |
| 12646019 |
48 |
Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. |
Sugen |
| 11063616 |
45 |
3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. |
University of Auckland |
| 2552117 |
68 |
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. |
Hebrew University of Jerusalem |
| 28796488 |
9 |
Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide. |
Novartis Pharma |
| 18589438 |
10 |
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. |
University of Otago |
| 8523406 |
59 |
Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs. |
Eli Lilly |
| 11170625 |
25 |
Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors. |
Uppsala University |
| 12887776 |
4 |
[BRCA1 protein expression in sporadic breast and its clinical significance]. |
Anhui Medical University |
| 17426033 |
5 |
Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator. |
University of Toronto |
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