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PubMed code 21985377

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ribosomal protein S6 kinase alpha-1


(Homo sapiens (Human))		BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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UniChem
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n/an/a 970n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
ETS domain-containing protein Elk-1


(Homo sapiens (Human))		BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1


(Homo sapiens (Human))		BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 1.38E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
ETS domain-containing protein Elk-1


(Homo sapiens (Human))		BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 1.53E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1


(Homo sapiens (Human))		BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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n/an/a 1.93E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
ETS domain-containing protein Elk-1


(Homo sapiens (Human))		BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 1.95E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
ETS domain-containing protein Elk-1


(Homo sapiens (Human))		BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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n/an/a 2.42E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
ETS domain-containing protein Elk-1


(Homo sapiens (Human))		BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 2.47E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1


(Homo sapiens (Human))		BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 2.71E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1


(Homo sapiens (Human))		BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 2.76E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 3.12E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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n/an/a 3.21E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 3.28E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237220
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1, 3-diphenylthioure...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2)ccc1O
Show InChI InChI=1S/C21H20N2O2S/c1-25-20-14-16(12-13-19(20)24)15-23(18-10-6-3-7-11-18)21(26)22-17-8-4-2-5-9-17/h2-14,24H,15H2,1H3,(H,22,26)
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n/an/a 3.35E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237213
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 4.07E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237230
PNG
(1-(2, 4-Dichlorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2Cl)ccc1O
Show InChI InChI=1S/C21H18Cl2N2O2S/c1-27-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(28)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,28)
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n/an/a 4.13E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237212
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 4.19E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237219
PNG
(1-(2, 4-Dichlorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Cl)cc2Cl)ccc1O
Show InChI InChI=1S/C21H18Cl2N2O3/c1-28-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(27)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,27)
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n/an/a 5.22E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237221
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-3-phenyl-1-p-tolylth...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C22H22N2O2S/c1-16-8-11-19(12-9-16)24(22(27)23-18-6-4-3-5-7-18)15-17-10-13-20(25)21(14-17)26-2/h3-14,25H,15H2,1-2H3,(H,23,27)
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n/an/a 5.47E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237211
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c1-27-19-11-9-18(10-12-19)24(22(26)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)28-2/h3-14,25H,15H2,1-2H3,(H,23,26)
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n/an/a 5.76E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237210
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-3-phenyl-1-p-tolylur...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C22H22N2O3/c1-16-8-11-19(12-9-16)24(22(26)23-18-6-4-3-5-7-18)15-17-10-13-20(25)21(14-17)27-2/h3-14,25H,15H2,1-2H3,(H,23,26)
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n/an/a 6.12E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237228
PNG
(1-(2-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2Br)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(27)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 6.14E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237218
PNG
(1-(2, 4-Difluorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(F)cc2F)ccc1O
Show InChI InChI=1S/C21H18F2N2O3/c1-28-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(27)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,27)
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n/an/a 6.47E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237209
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1, 3-diphenylurea (1...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2)ccc1O
Show InChI InChI=1S/C21H20N2O3/c1-26-20-14-16(12-13-19(20)24)15-23(18-10-6-3-7-11-18)21(25)22-17-8-4-2-5-9-17/h2-14,24H,15H2,1H3,(H,22,25)
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n/an/a 6.77E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237229
PNG
(1-(2, 4-Difluorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2F)ccc1O
Show InChI InChI=1S/C21H18F2N2O2S/c1-27-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(28)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,28)
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n/an/a 6.92E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237227
PNG
(1-(2-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2Cl)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(27)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 6.99E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237226
PNG
(1-(2-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2F)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(27)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 7.22E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237215
PNG
(1-(2-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2F)ccc1O
Show InChI InChI=1S/C21H19FN2O3/c1-27-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(26)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 9.15E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237216
PNG
(1-(2-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2Cl)ccc1O
Show InChI InChI=1S/C21H19ClN2O3/c1-27-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(26)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 1.01E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237217
PNG
(1-(2-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2Br)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(26)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2


(Homo sapiens (Human))		BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 1.78E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2


(Homo sapiens (Human))		BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 1.96E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 2.27E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2


(Homo sapiens (Human))		BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2


(Homo sapiens (Human))		BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2


(Homo sapiens (Human))		BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1/3


(Homo sapiens (Human))		BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...

J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%