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PubMed code 11063616

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4615
PNG
(1,6-naphthyridine deriv. 17 | N-[2-[[(tert-Butylam...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(C)=O)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C23H27N5O4/c1-13(29)25-20-11-19-15(12-24-20)9-18(14-7-16(31-5)10-17(8-14)32-6)21(26-19)27-22(30)28-23(2,3)4/h7-12H,1-6H3,(H,24,25,29)(H2,26,27,28,30)
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n/an/a 25n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4612
PNG
(1,6-naphthyridine deriv. 14 | 1-[7-amino-3-(3,5-di...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C19H21N5O3/c1-4-21-19(25)24-18-15(7-12-10-22-17(20)9-16(12)23-18)11-5-13(26-2)8-14(6-11)27-3/h5-10H,4H2,1-3H3,(H2,20,22)(H2,21,23,24,25)
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n/an/a 29n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 31n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4613
PNG
(1,6-naphthyridine deriv. 15 | 1-[7-amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C21H25N5O3/c1-21(2,3)26-20(27)25-19-16(8-13-11-23-18(22)10-17(13)24-19)12-6-14(28-4)9-15(7-12)29-5/h6-11H,1-5H3,(H2,22,23)(H2,24,25,26,27)
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n/an/a 42n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4616
PNG
(1,6-naphthyridine deriv. 18 | N-[2-Amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)C(F)(F)F)cc2nc1N
Show InChI InChI=1S/C18H15F3N4O3/c1-27-11-3-9(4-12(6-11)28-2)13-5-10-8-23-15(7-14(10)24-16(13)22)25-17(26)18(19,20)21/h3-8H,1-2H3,(H2,22,24)(H,23,25,26)
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n/an/a 61n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4611
PNG
(1,6-naphthyridine deriv. 13 | 1-[7-amino-3-(3,5-di...)
Show SMILES CNC(=O)Nc1nc2cc(N)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C18H19N5O3/c1-20-18(24)23-17-14(6-11-9-21-16(19)8-15(11)22-17)10-4-12(25-2)7-13(5-10)26-3/h4-9H,1-3H3,(H2,19,21)(H2,20,22,23,24)
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n/an/a 95n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4608
PNG
(1,6-naphthyridine deriv. 10 | 1-[7-amino-3-(2,6-di...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1c(Cl)cccc1Cl |(-.23,-6.63,;1.1,-5.86,;1.1,-4.32,;2.43,-3.55,;3.77,-4.32,;2.43,-2.01,;1.1,-1.24,;-.23,-2.01,;-1.57,-1.18,;-2.9,-1.95,;-4.23,-1.18,;-5.57,-1.95,;-4.23,.36,;-2.9,1.13,;-1.57,.36,;-.23,1.07,;1.1,.3,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C17H15Cl2N5O/c1-2-21-17(25)24-16-10(15-11(18)4-3-5-12(15)19)6-9-8-22-14(20)7-13(9)23-16/h3-8H,2H2,1H3,(H2,20,22)(H2,21,23,24,25)
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n/an/a 100n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4609
PNG
(1,6-naphthyridine deriv. 11 | 1-[7-amino-3-(2,6-di...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2cc(N)ncc2cc1-c1c(Cl)cccc1Cl |(-.23,-6.63,;1.1,-5.86,;1.1,-7.4,;2.59,-6.26,;1.1,-4.32,;2.43,-3.55,;3.77,-4.32,;2.43,-2.01,;1.1,-1.24,;-.23,-2.01,;-1.57,-1.18,;-2.9,-1.95,;-4.23,-1.18,;-5.57,-1.95,;-4.23,.36,;-2.9,1.13,;-1.57,.36,;-.23,1.07,;1.1,.3,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C19H19Cl2N5O/c1-19(2,3)26-18(27)25-17-11(16-12(20)5-4-6-13(16)21)7-10-9-23-15(22)8-14(10)24-17/h4-9H,1-3H3,(H2,22,23)(H2,24,25,26,27)
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n/an/a 120n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4608
PNG
(1,6-naphthyridine deriv. 10 | 1-[7-amino-3-(2,6-di...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1c(Cl)cccc1Cl |(-.23,-6.63,;1.1,-5.86,;1.1,-4.32,;2.43,-3.55,;3.77,-4.32,;2.43,-2.01,;1.1,-1.24,;-.23,-2.01,;-1.57,-1.18,;-2.9,-1.95,;-4.23,-1.18,;-5.57,-1.95,;-4.23,.36,;-2.9,1.13,;-1.57,.36,;-.23,1.07,;1.1,.3,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C17H15Cl2N5O/c1-2-21-17(25)24-16-10(15-11(18)4-3-5-12(15)19)6-9-8-22-14(20)7-13(9)23-16/h3-8H,2H2,1H3,(H2,20,22)(H2,21,23,24,25)
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n/an/a 150n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4617
PNG
(1,6-naphthyridine deriv. 19 | 3-tert-butyl-1-{7-[(...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)NC(C)(C)C)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C26H34N6O4/c1-25(2,3)31-23(33)29-21-13-20-16(14-27-21)11-19(15-9-17(35-7)12-18(10-15)36-8)22(28-20)30-24(34)32-26(4,5)6/h9-14H,1-8H3,(H2,27,29,31,33)(H2,28,30,32,34)
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n/an/a 160n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4609
PNG
(1,6-naphthyridine deriv. 11 | 1-[7-amino-3-(2,6-di...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2cc(N)ncc2cc1-c1c(Cl)cccc1Cl |(-.23,-6.63,;1.1,-5.86,;1.1,-7.4,;2.59,-6.26,;1.1,-4.32,;2.43,-3.55,;3.77,-4.32,;2.43,-2.01,;1.1,-1.24,;-.23,-2.01,;-1.57,-1.18,;-2.9,-1.95,;-4.23,-1.18,;-5.57,-1.95,;-4.23,.36,;-2.9,1.13,;-1.57,.36,;-.23,1.07,;1.1,.3,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C19H19Cl2N5O/c1-19(2,3)26-18(27)25-17-11(16-12(20)5-4-6-13(16)21)7-10-9-23-15(22)8-14(10)24-17/h4-9H,1-3H3,(H2,22,23)(H2,24,25,26,27)
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n/an/a 170n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4610
PNG
(1,6-naphthyridine deriv. 12 | 3-(3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1N
Show InChI InChI=1S/C16H16N4O2/c1-21-11-3-9(4-12(6-11)22-2)13-5-10-8-19-15(17)7-14(10)20-16(13)18/h3-8H,1-2H3,(H2,17,19)(H2,18,20)
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n/an/a 200n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4614
PNG
(1,6-naphthyridine deriv. 16 | 3-[7-amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1NC(=O)Nc1ccccc1
Show InChI InChI=1S/C23H21N5O3/c1-30-17-8-14(9-18(11-17)31-2)19-10-15-13-25-21(24)12-20(15)27-22(19)28-23(29)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,28,29)
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n/an/a 510n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4607
PNG
(1,6-naphthyridine deriv. 9 | 3-(2,6-dichlorophenyl...)
Show SMILES Nc1cc2nc(N)c(cc2cn1)-c1c(Cl)cccc1Cl |(-5.57,-1.95,;-4.23,-1.18,;-2.9,-1.95,;-1.57,-1.18,;-.23,-2.01,;1.1,-1.24,;2.43,-2.01,;1.1,.3,;-.23,1.07,;-1.57,.36,;-2.9,1.13,;-4.23,.36,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C14H10Cl2N4/c15-9-2-1-3-10(16)13(9)8-4-7-6-19-12(17)5-11(7)20-14(8)18/h1-6H,(H2,17,19)(H2,18,20)
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n/an/a 680n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4605
PNG
(1,6-naphthyridine deriv. 7 | 1-(7-amino-3-phenyl-1...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C17H17N5O/c1-2-19-17(23)22-16-13(11-6-4-3-5-7-11)8-12-10-20-15(18)9-14(12)21-16/h3-10H,2H2,1H3,(H2,18,20)(H2,19,21,22,23)
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n/an/a 1.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4609
PNG
(1,6-naphthyridine deriv. 11 | 1-[7-amino-3-(2,6-di...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2cc(N)ncc2cc1-c1c(Cl)cccc1Cl |(-.23,-6.63,;1.1,-5.86,;1.1,-7.4,;2.59,-6.26,;1.1,-4.32,;2.43,-3.55,;3.77,-4.32,;2.43,-2.01,;1.1,-1.24,;-.23,-2.01,;-1.57,-1.18,;-2.9,-1.95,;-4.23,-1.18,;-5.57,-1.95,;-4.23,.36,;-2.9,1.13,;-1.57,.36,;-.23,1.07,;1.1,.3,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C19H19Cl2N5O/c1-19(2,3)26-18(27)25-17-11(16-12(20)5-4-6-13(16)21)7-10-9-23-15(22)8-14(10)24-17/h4-9H,1-3H3,(H2,22,23)(H2,24,25,26,27)
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n/an/a 1.80E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4606
PNG
(1,6-naphthyridine deriv. 8 | 1-(7-amino-3-phenyl-1...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2cc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-19(2,3)24-18(25)23-17-14(12-7-5-4-6-8-12)9-13-11-21-16(20)10-15(13)22-17/h4-11H,1-3H3,(H2,20,21)(H2,22,23,24,25)
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n/an/a 1.90E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4606
PNG
(1,6-naphthyridine deriv. 8 | 1-(7-amino-3-phenyl-1...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2cc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-19(2,3)24-18(25)23-17-14(12-7-5-4-6-8-12)9-13-11-21-16(20)10-15(13)22-17/h4-11H,1-3H3,(H2,20,21)(H2,22,23,24,25)
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n/an/a 2.60E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4607
PNG
(1,6-naphthyridine deriv. 9 | 3-(2,6-dichlorophenyl...)
Show SMILES Nc1cc2nc(N)c(cc2cn1)-c1c(Cl)cccc1Cl |(-5.57,-1.95,;-4.23,-1.18,;-2.9,-1.95,;-1.57,-1.18,;-.23,-2.01,;1.1,-1.24,;2.43,-2.01,;1.1,.3,;-.23,1.07,;-1.57,.36,;-2.9,1.13,;-4.23,.36,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C14H10Cl2N4/c15-9-2-1-3-10(16)13(9)8-4-7-6-19-12(17)5-11(7)20-14(8)18/h1-6H,(H2,17,19)(H2,18,20)
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n/an/a 2.80E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4615
PNG
(1,6-naphthyridine deriv. 17 | N-[2-[[(tert-Butylam...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(C)=O)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C23H27N5O4/c1-13(29)25-20-11-19-15(12-24-20)9-18(14-7-16(31-5)10-17(8-14)32-6)21(26-19)27-22(30)28-23(2,3)4/h7-12H,1-6H3,(H,24,25,29)(H2,26,27,28,30)
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4606
PNG
(1,6-naphthyridine deriv. 8 | 1-(7-amino-3-phenyl-1...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2cc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C19H21N5O/c1-19(2,3)24-18(25)23-17-14(12-7-5-4-6-8-12)9-13-11-21-16(20)10-15(13)22-17/h4-11H,1-3H3,(H2,20,21)(H2,22,23,24,25)
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n/an/a 4.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4615
PNG
(1,6-naphthyridine deriv. 17 | N-[2-[[(tert-Butylam...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(C)=O)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C23H27N5O4/c1-13(29)25-20-11-19-15(12-24-20)9-18(14-7-16(31-5)10-17(8-14)32-6)21(26-19)27-22(30)28-23(2,3)4/h7-12H,1-6H3,(H,24,25,29)(H2,26,27,28,30)
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4605
PNG
(1,6-naphthyridine deriv. 7 | 1-(7-amino-3-phenyl-1...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C17H17N5O/c1-2-19-17(23)22-16-13(11-6-4-3-5-7-11)8-12-10-20-15(18)9-14(12)21-16/h3-10H,2H2,1H3,(H2,18,20)(H2,19,21,22,23)
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4605
PNG
(1,6-naphthyridine deriv. 7 | 1-(7-amino-3-phenyl-1...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C17H17N5O/c1-2-19-17(23)22-16-13(11-6-4-3-5-7-11)8-12-10-20-15(18)9-14(12)21-16/h3-10H,2H2,1H3,(H2,18,20)(H2,19,21,22,23)
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n/an/a 7.70E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4608
PNG
(1,6-naphthyridine deriv. 10 | 1-[7-amino-3-(2,6-di...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1c(Cl)cccc1Cl |(-.23,-6.63,;1.1,-5.86,;1.1,-4.32,;2.43,-3.55,;3.77,-4.32,;2.43,-2.01,;1.1,-1.24,;-.23,-2.01,;-1.57,-1.18,;-2.9,-1.95,;-4.23,-1.18,;-5.57,-1.95,;-4.23,.36,;-2.9,1.13,;-1.57,.36,;-.23,1.07,;1.1,.3,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C17H15Cl2N5O/c1-2-21-17(25)24-16-10(15-11(18)4-3-5-12(15)19)6-9-8-22-14(20)7-13(9)23-16/h3-8H,2H2,1H3,(H2,20,22)(H2,21,23,24,25)
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n/an/a 1.10E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4604
PNG
(1,6-naphthyridine deriv. 6 | 3-phenyl-1,6-naphthyr...)
Show SMILES Nc1cc2nc(N)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C14H12N4/c15-13-7-12-10(8-17-13)6-11(14(16)18-12)9-4-2-1-3-5-9/h1-8H,(H2,15,17)(H2,16,18)
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n/an/a 1.70E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4604
PNG
(1,6-naphthyridine deriv. 6 | 3-phenyl-1,6-naphthyr...)
Show SMILES Nc1cc2nc(N)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C14H12N4/c15-13-7-12-10(8-17-13)6-11(14(16)18-12)9-4-2-1-3-5-9/h1-8H,(H2,15,17)(H2,16,18)
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n/an/a 1.70E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4604
PNG
(1,6-naphthyridine deriv. 6 | 3-phenyl-1,6-naphthyr...)
Show SMILES Nc1cc2nc(N)c(cc2cn1)-c1ccccc1
Show InChI InChI=1S/C14H12N4/c15-13-7-12-10(8-17-13)6-11(14(16)18-12)9-4-2-1-3-5-9/h1-8H,(H2,15,17)(H2,16,18)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4607
PNG
(1,6-naphthyridine deriv. 9 | 3-(2,6-dichlorophenyl...)
Show SMILES Nc1cc2nc(N)c(cc2cn1)-c1c(Cl)cccc1Cl |(-5.57,-1.95,;-4.23,-1.18,;-2.9,-1.95,;-1.57,-1.18,;-.23,-2.01,;1.1,-1.24,;2.43,-2.01,;1.1,.3,;-.23,1.07,;-1.57,.36,;-2.9,1.13,;-4.23,.36,;2.43,1.07,;3.78,.32,;3.78,-1.22,;5.1,1.11,;5.08,2.65,;3.73,3.4,;2.41,2.61,;1.08,3.38,)|
Show InChI InChI=1S/C14H10Cl2N4/c15-9-2-1-3-10(16)13(9)8-4-7-6-19-12(17)5-11(7)20-14(8)18/h1-6H,(H2,17,19)(H2,18,20)
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n/an/a 3.50E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4613
PNG
(1,6-naphthyridine deriv. 15 | 1-[7-amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C21H25N5O3/c1-21(2,3)26-20(27)25-19-16(8-13-11-23-18(22)10-17(13)24-19)12-6-14(28-4)9-15(7-12)29-5/h6-11H,1-5H3,(H2,22,23)(H2,24,25,26,27)
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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n/an/a 4.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4614
PNG
(1,6-naphthyridine deriv. 16 | 3-[7-amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1NC(=O)Nc1ccccc1
Show InChI InChI=1S/C23H21N5O3/c1-30-17-8-14(9-18(11-17)31-2)19-10-15-13-25-21(24)12-20(15)27-22(19)28-23(29)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4613
PNG
(1,6-naphthyridine deriv. 15 | 1-[7-amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C21H25N5O3/c1-21(2,3)26-20(27)25-19-16(8-13-11-23-18(22)10-17(13)24-19)12-6-14(28-4)9-15(7-12)29-5/h6-11H,1-5H3,(H2,22,23)(H2,24,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4617
PNG
(1,6-naphthyridine deriv. 19 | 3-tert-butyl-1-{7-[(...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)NC(C)(C)C)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C26H34N6O4/c1-25(2,3)31-23(33)29-21-13-20-16(14-27-21)11-19(15-9-17(35-7)12-18(10-15)36-8)22(28-20)30-24(34)32-26(4,5)6/h9-14H,1-8H3,(H2,27,29,31,33)(H2,28,30,32,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4610
PNG
(1,6-naphthyridine deriv. 12 | 3-(3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1N
Show InChI InChI=1S/C16H16N4O2/c1-21-11-3-9(4-12(6-11)22-2)13-5-10-8-19-15(17)7-14(10)20-16(13)18/h3-8H,1-2H3,(H2,17,19)(H2,18,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4614
PNG
(1,6-naphthyridine deriv. 16 | 3-[7-amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1NC(=O)Nc1ccccc1
Show InChI InChI=1S/C23H21N5O3/c1-30-17-8-14(9-18(11-17)31-2)19-10-15-13-25-21(24)12-20(15)27-22(19)28-23(29)26-16-6-4-3-5-7-16/h3-13H,1-2H3,(H2,24,25)(H2,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4616
PNG
(1,6-naphthyridine deriv. 18 | N-[2-Amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)C(F)(F)F)cc2nc1N
Show InChI InChI=1S/C18H15F3N4O3/c1-27-11-3-9(4-12(6-11)28-2)13-5-10-8-23-15(7-14(10)24-16(13)22)25-17(26)18(19,20)21/h3-8H,1-2H3,(H2,22,24)(H,23,25,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4617
PNG
(1,6-naphthyridine deriv. 19 | 3-tert-butyl-1-{7-[(...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)NC(C)(C)C)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C26H34N6O4/c1-25(2,3)31-23(33)29-21-13-20-16(14-27-21)11-19(15-9-17(35-7)12-18(10-15)36-8)22(28-20)30-24(34)32-26(4,5)6/h9-14H,1-8H3,(H2,27,29,31,33)(H2,28,30,32,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4611
PNG
(1,6-naphthyridine deriv. 13 | 1-[7-amino-3-(3,5-di...)
Show SMILES CNC(=O)Nc1nc2cc(N)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C18H19N5O3/c1-20-18(24)23-17-14(6-11-9-21-16(19)8-15(11)22-17)10-4-12(25-2)7-13(5-10)26-3/h4-9H,1-3H3,(H2,19,21)(H2,20,22,23,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4618
PNG
(1,6-naphthyridine 14 | 1,6-naphthyridine deriv. 20...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C28H38N6O4/c1-28(2,3)33-27(35)32-26-23(19-13-21(36-4)16-22(14-19)37-5)15-20-18-30-25(17-24(20)31-26)29-7-6-8-34-9-11-38-12-10-34/h13-18H,6-12H2,1-5H3,(H,29,30)(H2,31,32,33,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4612
PNG
(1,6-naphthyridine deriv. 14 | 1-[7-amino-3-(3,5-di...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C19H21N5O3/c1-4-21-19(25)24-18-15(7-12-10-22-17(20)9-16(12)23-18)11-5-13(26-2)8-14(6-11)27-3/h5-10H,4H2,1-3H3,(H2,20,22)(H2,21,23,24,25)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4611
PNG
(1,6-naphthyridine deriv. 13 | 1-[7-amino-3-(3,5-di...)
Show SMILES CNC(=O)Nc1nc2cc(N)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C18H19N5O3/c1-20-18(24)23-17-14(6-11-9-21-16(19)8-15(11)22-17)10-4-12(25-2)7-13(5-10)26-3/h4-9H,1-3H3,(H2,19,21)(H2,20,22,23,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4616
PNG
(1,6-naphthyridine deriv. 18 | N-[2-Amino-3-(3,5-di...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)C(F)(F)F)cc2nc1N
Show InChI InChI=1S/C18H15F3N4O3/c1-27-11-3-9(4-12(6-11)28-2)13-5-10-8-23-15(7-14(10)24-16(13)22)25-17(26)18(19,20)21/h3-8H,1-2H3,(H2,22,24)(H,23,25,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4610
PNG
(1,6-naphthyridine deriv. 12 | 3-(3,5-dimethoxyphen...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)cc2nc1N
Show InChI InChI=1S/C16H16N4O2/c1-21-11-3-9(4-12(6-11)22-2)13-5-10-8-19-15(17)7-14(10)20-16(13)18/h3-8H,1-2H3,(H2,17,19)(H2,18,20)
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4612
PNG
(1,6-naphthyridine deriv. 14 | 1-[7-amino-3-(3,5-di...)
Show SMILES CCNC(=O)Nc1nc2cc(N)ncc2cc1-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C19H21N5O3/c1-4-21-19(25)24-18-15(7-12-10-22-17(20)9-16(12)23-18)11-5-13(26-2)8-14(6-11)27-3/h5-10H,4H2,1-3H3,(H2,20,22)(H2,21,23,24,25)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 4200-11 (2000)


Article DOI: 10.1021/jm061108d
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%