47 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
26619267	29	3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.	Mcgill University
25894999	3	Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum.	Medical University of Vienna
24948566	11	Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells.	Riken
24617858	239	Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP).	University of Antwerp
24763264	7	Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo.	University of Helsinki
24660890	12	Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.	Merck
24900696	72	Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold.	University of Antwerp (Ua)
23594271	68	Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.	Tufts University Sackler School of Biomedical Sciences
22765237	28	Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells.	Mcgill University
22525314	159	Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity.	University of Antwerp (Ua)
20627594	2	Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide.	The University of Warwick
20058865	59	Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors.	Mcgill University
15730241	12	Bioactive constituents from Boswellia papyrifera.	University of Karachi
18053726	364	Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.	Johnson & Johnson Pharmaceutical Research & Development
17331715	19	Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors.	Korea Research Institute of Chemical Technology
8642568	28	Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides.	Boehringer Ingelheim Pharmaceuticals
8027988	37	New potent prolyl endopeptidase inhibitors: synthesis and structure-activity relationships of indan and tetralin derivatives and their analogues.	Zeria Pharmaceutical
21865048	29	2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A.	Dainippon Sumitomo Pharma
21324688	36	1-((3S,4S)-4-amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes.	Pfizer
19888757	30	Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors.	Mcgill University
19643608	58	Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor.	Torrent Pharmaceuticals
19833514	104	The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.	Santhera Pharmaceuticals (Switzerland)
	9	Synthesis of peptidyl acetals as inhibitors of prolyl endopeptidase	TBA
19275964	64	(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.	Pfizer
18650094	12	Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor.	Institut De Recerca BiomèDica De Barcelona
18602260	177	Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors.	Ranbaxy Research Laboratories
17174090	50	Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP.	Genentech
17055271	18	Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.	Tufts University School of Medicine
15380217	87	Potent and selective proline derived dipeptidyl peptidase IV inhibitors.	Merck
15012982	129	Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.	Merck Research Laboratories
14611847	20	Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity.	University of Antwerp
10091698	12	Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.	Université
10090787	25	Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors.	University of Antwerp (Uia)
31393718	26	Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein ?.	Mcgill University
30701972	35	Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.	Charles University
9191969	31	Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives.	Institut De Recherche Servier
31732257	20	Discovery of covalent prolyl oligopeptidase boronic ester inhibitors.	Mcgill University
8691432	79	New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives.	Institut De Recherche Servier
18606544	42	Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP).	Glaxosmithkline
29429833	4	Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision.	Riken Csrs
28442252	62	Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.	Ranbaxy Laboratories
16954316	38	Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.	National Center For Genetic Engineering and Biotechnology At Thailand