The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28259840 |
83 |
Quinazoline derivatives as selective CYP1B1 inhibitors. |
Birla Institute of Technology |
28222316 |
165 |
Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. |
De Montfort University |
27265259 |
16 |
Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. |
Whittier College |
26222195 |
56 |
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. |
Xavier University of Louisiana |
25799264 |
94 |
Design and Synthesis of Newa-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression. |
Shanghai Jiao Tong University |
25089810 |
79 |
Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia. |
National Taiwan University |
23806553 |
7 |
Discovery of triazines as potent, selective and orally active PDE4 inhibitors. |
Biocrea |
23600958 |
57 |
Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. |
Xavier University of Louisiana |
16248836 |
154 |
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. |
F. Hoffmann-La Roche |
22863525 |
36 |
Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1. |
Poznan University of Medical Sciences |
18462007 |
7 |
Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara. |
Universidade Federal De Minas Gerais |
17544277 |
29 |
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. |
University of Maryland |
12852960 |
48 |
Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1. |
National Research Institute of Chinese Medicine |
22266038 |
55 |
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. |
Astrazeneca |
22079757 |
13 |
Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). |
Mcmaster University |
21482471 |
28 |
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. |
University of Crete |
21411321 |
28 |
Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate. |
Merck Research Laboratories |
20813430 |
5 |
Homology modeling and molecular dynamics of CYP1A1 and CYP2B1 to explore the metabolism of aryl derivatives by docking and experimental assays. |
Instituto PolitéCnico Nacional |
20696580 |
54 |
Selective inhibition of methoxyflavonoids on human CYP1B1 activity. |
University of Shizuoka |
16631366 |
26 |
Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides. |
Astrazeneca |
11754588 |
39 |
Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. |
Seoul National University |
30665142 |
41 |
Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy. |
De Montfort University |
31257085 |
24 |
Strategies for the development of highly selective cytochrome P450 inhibitors: Several CYP targets in current research. |
Shenyang Pharmaceutical University |
31830634 |
126 |
Synthesis and structure-activity relationship studies of ?-naphthoflavone derivatives as CYP1B1 inhibitors. |
Shanghai Jiao Tong University |
30638874 |
64 |
Discovery of new indole-based acylsulfonamide Na |
Bristol-Myers Squibb Research and Development |
30503941 |
21 |
Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1. |
Birla Institute of Technology |
30613334 |
12 |
Adaptable Small Ligand of CYP1 Enzymes for Use in Understanding the Structural Features Determining Isoform Selectivity. |
Seoul National University |
31675512 |
3 |
Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties. |
Universitat De Barcelona |
30553624 |
40 |
Design and synthesis of selective CYP1B1 inhibitor via dearomatization of ?-naphthoflavone. |
Showa Pharmaceutical University |
16789754 |
4 |
Structural studies on bioactive compounds. 40.(1) Synthesis and biological properties of fluoro-, methoxyl-, and amino-substituted 3-phenyl-4H-1-benzopyran-4-ones and a comparison of their antitumor activities with the activities of related 2-phenylbenzothiazoles. |
University of Nottingham |
30216063 |
10 |
Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-Ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity, and Selectivity. |
Chu De Qu£Bec-Research Center |
29150398 |
42 |
Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. |
Csir-Indian Institute of Integrative Medicine |
29138024 |
213 |
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent. |
De Montfort University |
28711350 |
195 |
Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance. |
De Montfort University |
28458135 |
109 |
Inhibitors of cytochrome P450 (CYP) 1B1. |
Universit£ |
28535350 |
3 |
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells. |
H�Pital Saint-Fran�Ois D'Assise |