The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28523109 |
79 |
Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4. |
Glaxosmithkline |
| 27964995 |
42 |
Synthesis and optimization of novela-phenylglycinamides as selective TRPM8 antagonists. |
Kissei Pharmaceutical |
| 26235950 |
41 |
Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. |
Renovis |
| 25893043 |
36 |
Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain. |
Pfizer |
| 25455494 |
172 |
Effect of acyclic monoterpene alcohols and their derivatives on TRP channels. |
Sapienza University of Rome |
| 25455182 |
52 |
Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. |
Raqualia Pharma |
| 24884675 |
70 |
Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. |
Genomics Institute of The Novartis Research Foundation |
| 24597733 |
57 |
Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists. |
Amgen |
| 24080460 |
24 |
Serendipity in drug-discovery: a new series of 2-(benzyloxy)benzamides as TRPM8 antagonists. |
Pfizer |
| 24055075 |
42 |
Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists. |
Glenmark Pharmaceuticals |
| 23121096 |
86 |
Ion channels as therapeutic targets: a drug discovery perspective. |
Pfizer |
| 21128593 |
44 |
Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. |
Janssen Pharmaceutica |
| 20570528 |
34 |
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists. |
Abbott Laboratories |
| 20356305 |
151 |
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. |
Ferrara University |
| 22330635 |
25 |
Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia. |
Janssen Pharmaceutica |
| 21634377 |
73 |
Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. |
Amgen |
| 20965726 |
20 |
5-benzyloxytryptamine as an antagonist of TRPM8. |
Renovis |
| 17293875 |
3 |
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. |
Ku Leuven |
| 32787109 |
45 |
Exploration of TRPM8 Binding Sites by ?-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities. |
University of Salerno |
| 30507122 |
4 |
Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity. |
University of Utah |
| 30500190 |
36 |
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model. |
TBA |
| 30878828 |
109 |
N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. |
University of Hull |
| 29939028 |
17 |
Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. |
University of Salerno |
| 30148953 |
75 |
Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. |
TBA |
| 30335378 |
25 |
Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4). |
TBA |
| 29723786 |
9 |
Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors. |
Peking University |
| 28740604 |
22 |
Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound. |
Kao |
| 28662813 |
80 |
Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents. |
Senomyx |
| 29590749 |
24 |
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling. |
Pharmaron-Beijing |
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